Figure 6. Simulation of SPRs for mutant phenotypes using the three-state model. Simulated mean SPRs predicted by the three-state model are shown. The wild-type (WT) response is the same as in Figure 4E and was averaged from 10⁵ simulations. The remaining traces were each averaged from 10⁴ simulations. The hemizygote responses (dashed traces) for Arr^+/− (red) and GRK1^+/− (blue) were obtained by halving the respective rate parameter, μ or ν, from the value shown in Table 1. The knockout responses (solid traces) for Arr^−/− (red) and GRK1^−/− (blue) were obtained by reducing the respective rate parameter, μ or ν, to zero.