Figure 5. Cyp1b1 expression at 11.5 dpc

A: Lateral view of the whole mount. Note alterations in the polarity of Cyp1b1 expression in developing eye and forelimb (as compared to Figure 3A and Figure 4A). The forelimb bud (fb), hindlimb bud (hb), lateral nasal process (lnp), mandibular component of the first branchial arch (mb), maxillary component of the first branchial arch (mx), nasolacrimal groove between the maxillary component of the first branchial arch and the lateral nasal process (ns), region overlying the telencephalic vesicle (tv), and second branchial arch (II) are also labeled. B: Lateral view focused on the expression domains in the developing eye, pharyngeal region and forelimb bud. The insert represents control eye hybridized with sense probe. C: Frontal (coronal) section through the optic region. Corneal ectoderm (epithelium) (1), cavity of the lens vesicle (2), lens epithelium (3), future hyaloid cavity (4), inner (neural) layer of the optic cup representing the future nervous layer of the retina (5), and the outer layer of the optic cup representing the future pigmented layer of the retina (6) are numbered. For orientation, dorso-distal (DD) and proximo-ventral (PV) are labeled. D: Sagittal section through the optic region. For orientation, anterior nasal (AN) and posterior temporal (PT) are labeled. E: Frontal (coronal) section through the oropharyngeal region. The oropharynx (oph) is labeled. F: Coronal section through the forelimb bud. The apical ectodermal ridge (aer), ectoderm (ec), and mesenchyme (ms) are also labeled. G: Hindbrain expression domain. The fourth ventricle (IV) is labeled. H: Cyp1b1 expression in the ligaments supporting the liver primordium (lp). The developing heart (h) is labeled. I: Close up view of the branching metanephric diverticulum (mtn), which is directed rostrally and has a dilated end. For orientation, anterior (A), posterior (P), dorsal (D), and ventral (V) are labeled. The bar represents a length of 1 mm.