Molecular Vision - A
        Peer-Reviewed Journal (60.6K)

Volume 23 (2017)

Quantitative proteomics analysis with iTRAQ in human lenses with nuclear cataracts of different axial lengths
Kyungsang Yoo, Bo Kwon Son, Suna Kim, Youngsook Son, Seung-Young Yu, Hyun Sook Hong, Haiyan Zhou, Hong Yan, Weijia Yan, Xinchuan Wang, Yong Ma, Jianping Wang
Published: 31 July 2016 [Full Text]

Possible involvement of NETosis in inflammatory processes in the eye: Evidence from a small cohort of patients
Tilda Barliya, Rima Dardik, Yael Nisgav, Mor Dachbash, Dan Gaton, Gili Kenet, Rita Ehrlich, Dov Weinberger, Tami Livnat
Published: 13 December 2017 [Full Text]

Post-ischemic treatment with azithromycin protects ganglion cells against retinal ischemia/reperfusion injury in the rat
Giuseppe Pasquale Varano, Vincenzo Parisi, Annagrazia Adornetto, Federica Cavaliere, Diana Amantea, Carlo Nucci, Maria Tiziana Corasaniti, Luigi Antonio Morrone, Giacinto Bagetta, Rossella Russo
Published: 11 December 2017 [Full Text]

Fisetin inhibits epidermal growth factor–induced migration of ARPE-19 cells by suppression of AKT activation and Sp1-dependent MMP-9 expression
Hung-Yu Lin, Yong-Syuan Chen, Kai Wang, Hsiang-Wen Chien, Yi-Hsien Hsieh, Shun-Fa Yang
Published: 10 December 2017 [Full Text]

Characterizing the effect of supplements on the phenotype of cultured macrophages from patients with age-related macular degeneration
Batya Rinsky, Shira Hagbi-Levi, Sarah Elbaz-Hayoun, Michelle Grunin, Itay Chowers
Published: 06 December 2017 [Full Text]

The retina/RPE proteome in chick myopia and hyperopia models: Commonalities with inherited and age-related ocular pathologies
Nina Riddell, Pierre Faou, Melanie Murphy, Loretta Giummarra, Rachael A. Downs, Harinda Rajapaksha, Sheila G. Crewther
Published: 05 December 2017 [Full Text]

Association of HMGB1 with oxidative stress markers and regulators in PDR
Ahmed M. Abu El-Asrar, Kaiser Alam, Marta Garcia-Ramirez, Ajmal Ahmad, Mohammad Mairaj Siddiquei, Ghulam Mohammad, Ahmed Mousa, Gert De Hertogh, Ghislain Opdenakker, Rafael Simó
Published: 05 December 2017 [Full Text]

Melatonin partially protects 661W cells from H2O2-induced death by inhibiting Fas/FasL-caspase-3
Aída Sánchez-Bretaño, Kenkichi Baba, Uzair Janjua, Ilaria Piano, Claudia Gargini, Gianluca Tosini
Published: 03 December 2017 [Full Text]

Effect of subretinal injection on retinal structure and function in a rat oxygen-induced retinopathy model
Silke Becker, Haibo Wang, Gregory J. Stoddard, M. Elizabeth Hartnett
Published: 29 November 2017 [Full Text]

Antiangiogenic effect of dasatinib in murine models of oxygen-induced retinopathy and laser-induced choroidal neovascularization
Songyi Seo, Wonhee Suh
Published: 24 November 2017 [Full Text]

Corneal regeneration by induced human buccal mucosa cultivated on an amniotic membrane following alkaline injury
Rohaina Che Man, Then Kong Yong, Ng Min Hwei, Wan Haslina Wan Abdul Halim, Aida Zairani Mohd Zahidin, Roszalina Ramli, Aminuddin Bin Saim, Ruszymah Binti Hj Idrus
Published: 21 November 2017 [Full Text]

Ciliary neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract
Alexander A. Shpak, Alla B. Guekht, Tatiana A. Druzhkova, Ksenia I. Kozlova, Natalia V. Gulyaeva
Published: 17 November 2017 [Full Text]

α-adrenergic agonist brimonidine control of experimentally induced myopia in guinea pigs: A pilot study
Yan Liu, Yuexin Wang, Huibin Lv, Xiaodan Jiang, Mingzhou Zhang, Xuemin Li
Published: 15 November 2017 [Full Text]

Heterozygous mutation in OTX2 associated with early-onset retinal dystrophy with atypical maculopathy
Maram EA Abdalla-Elsayed, Patrik Schatz, Christine Neuhaus, Arif O. Khan
Published: 13 November 2017 [Full Text]

Expression of CCL2 and its receptor in activation and migration of microglia and monocytes induced by photoreceptor apoptosis
ChaoYi Feng, Xin Wang, TianJin Liu, Meng Zhang, GeZhi Xu, YingQin Ni
Published: 01 November 2017 [Full Text]

Corneal lenticule storage before reimplantation
Yu-Chi Liu, Geraint P. Williams, Ben L. George, Yu Qiang Soh, Xin Yi Seah, Gary Swee Lim Peh, Gary Hin Fai Yam, Jodhbir S. Mehta
Published: 27 October 2017 [Full Text]

Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function
Marina Zakharevich, Jaffer M. Kattan, Judy L. Chen, Benjamin R. Lin, Aleck E. Cervantes, Doug D. Chung, Ricardo F. Frausto, Anthony J. Aldave
Published: 14 October 2017 [Full Text]

Enhancing the efficacy of AREDS antioxidants in light-induced retinal degeneration
Paul Wong, M. Markey, C. M. Rapp, R. M. Darrow, A. Ziesel, D.T. Organisciak
Published: 10 October 2017 [Full Text]

Retinal gene expression responses to aging are sexually divergent
Mei Du, Colleen A. Mangold, Georgina V. Bixler, Robert M. Brucklacher, Dustin R. Masser, Michael B. Stout, Michael H. Elliott, Willard M. Freeman
Published: 10 October 2017 [Full Text]

The importance of genetic testing as demonstrated by two cases of CACNA1F-associated retinal generation misdiagnosed as LCA
Clara J. Men, Kinga M. Bujakowska, Jason Comander, Emily Place, Emma C. Bedoukian, Xiaosong Zhu, Bart P. Leroy, Anne B. Fulton, Eric A. Pierce
Published: 10 October 2017 [Full Text]

Multicellular tumor spheroids of human uveal melanoma induce genes associated with anoikis resistance, lipogenesis, and SSXs
Charlotte Ness, Øystein Garred, Nils A. Eide, Theresa Kumar, Ole K. Olstad, Thomas P. Bærland, Goran Petrovski, Morten C. Moe, Agate Noer
Published: 03 October 2017 [Full Text]

Myopia induced by flickering light in guinea pig eyes is associated with increased rather than decreased dopamine release
Xiumei Luo, Bing Li, Tao Li, Yue Di, Changyue Zheng, Shunmei Ji, Yuanyuan Ma, Jie Zhu, Xuefeng Chen, Xiaodong Zhou
Published: 29 September 2017 [Full Text]

Genome-wide linkage and association analysis of primary open-angle glaucoma endophenotypes in the Norfolk Island isolate
Elizabeth Matovinovic, Pik Fang Kho, Rodney A. Lea, Miles C. Benton, David A. Eccles, Larisa M. Haupt, Alex W. Hewitt, Justin C. Sherwin, David A. Mackey, Lyn R. Griffiths
Published: 28 September 2017 [Full Text]

Diagnostic application of clinical exome sequencing in Leber congenital amaurosis
Jinu Han, John Hoon Rim, In Sik Hwang, Jieun Kim, Saeam Shin, Seung-Tae Lee, Jong Rak Choi
Published: 20 September 2017 [Full Text]

Pinus densiflora bark extract prevents selenite-induced cataract formation in the lens of Sprague Dawley rat pups
Jun Kim, Se-Young Choung
Published: 11 September 2017 [Full Text]

A novel truncation mutation in CRYBB1 associated with autosomal dominant congenital cataract with nystagmus
Yan Rao, Sufang Dong, Zuhua Li, Guohua Yang, Chunyan Peng, Ming Yan, Fang Zheng
Published: 01 September 2017 [Full Text]

A DNA dot hybridization model for molecular diagnosis of parasitic keratitis
Fu-Chin Huang, Hsin-Yi Hsieh, Tsung C. Chang, Shu-Li Su, Shin-Ling Tseng, Yu-Hsuan Lai, Ming-Tse Kuo
Published: 24 August 2017 [Full Text]

Targeted next-generation sequencing analysis identifies novel mutations in families with severe familial exudative vitreoretinopathy
Xiao-Yan Huang, Hong Zhuang, Ji-Hong Wu, Jian-Kang Li, Fang-Yuan Hu, Yu Zheng, Laurent Christian Asker M. Tellier, Sheng-Hai Zhang, Feng-Juan Gao, Jian-Guo Zhang, Ge-Zhi Xu
Published: 23 August 2017 [Full Text]

Association and interaction of myopia with SNP markers rs13382811 and rs6469937 at ZFHX1B and SNTB1 in Han Chinese and European populations
Jiali Li, Xiaodong Jiao, Qingjiong Zhang, J. Fielding Hejtmancik
Published: 11 August 2017 [Full Text]

Heparanase mediates vascular endothelial growth factor gene transcription in high-glucose human retinal microvascular endothelial cells
Jie Hu, Jingwei Wang, Xuan Leng, Yijun Hu, Huangxuan Shen, Xin Song
Published: 10 August 2017 [Full Text]

Magnetic resonance imaging study of eye congenital birth defects in mouse model
Jing-Huei Lee, Zachary Tucker, Maureen Mongan, Qinghang Meng, Ying Xia
Published: 10 August 2017 [Full Text]

Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide
Tamar R. Grossman, Michele Carrer, Lijiang Shen, Robert B. Johnson, Lisa A. Hettrick, Scott P. Henry, Brett P. Monia, Michael L. McCaleb
Published: 10 August 2017 [Full Text]

Diagnostic genetic testing for patients with bilateral optic neuropathy and comparison of clinical features according to OPA1 mutation status
Eric D. Gaier, Katherine Boudreault, Isao Nakata, Maria Janessian, Philip Skidd, Elizabeth DelBono, Keri F. Allen, Louis R. Pasquale, Emily Place, Dean M. Cestari, Rebecca C. Stacy, Joseph F. Rizzo, Janey L. Wiggs
Published: 10 August 2017 [Full Text]

Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease
Zhixi Peng, Shaoqiu Jiang, Mingxing Wu, Xiyuan Zhou, Qian Wang
Published: 31 July 2017 [Full Text]

Concentrations of MUC16 and MUC5AC using three tear collection methods
Anna F. Ablamowicz, Jason J. Nichols
Published: 28 July 2017 [Full Text]

Taxifolin protects RPE cells against oxidative stress-induced apoptosis
Xiaobin Xie, Jun Feng, Zefeng Kang, Shoukang Zhang, Lixia Zhang, Yan Zhang, Xuefei Li, Youzhi Tang
Published: 27 July 2017 [Full Text]

ARMS2 variants may predict the 3-year outcome of photodynamic therapy for wet age-related macular degeneration
Shunichiro Nakai, Shigeru Honda, Wataru Matsumiya, Akiko Miki, Makoto Nakamura
Published: 26 July 2017 [Full Text]

The comparative safety of genipin versus UVA-riboflavin crosslinking of rabbit corneas
Wenjing Song, Yun Tang, Jing Qiao, Haili Li, Bei Rong, Songlin Yang, Yuan Wu, Xiaoming Yan
Published: 22 July 2017 [Full Text]

Sequence variants in four genes underlying Bardet-Biedl syndrome in consanguineous families
Asmat Ullah, Muhammad Umair, Maryam Yousaf, Sher Alam Khan, Muhammad Nazim-ud-din, Khadim Shah, Farooq Ahmad, Zahid Azeem, Ghazanfar Ali, Bader Alhaddad, Afzal Rafique, Abid Jan, Tobias B. Haack, Tim M. Strom, Thomas Meitinger, Tahseen Ghous, Wasim Ahmad
Published: 21 July 2017 [Full Text]

Optimization of a genotyping screening based on hydrolysis probes to detect the main mutations related to Leber hereditary optic neuropathy (LHON)
Fábio Tadeu Arrojo Martins, Paulo Maurício do Amor Divino Miranda, Marcela Scabello Amaral Fernandes, Andréa Trevas Maciel-Guerra, Edi Lúcia Sartorato
Published: 21 July 2017 [Full Text]

Next-generation sequencing to solve complex inherited retinal dystrophy: A case series of multiple genes contributing to disease in extended families
Kaylie D. Jones, Dianna K. Wheaton, Sara J. Bowne, Lori S. Sullivan, David G. Birch, Rui Chen, Stephen P. Daiger
Published: 20 July 2017 [Full Text]

The expression profile of developmental stage-dependent circular RNA in the immature rat retina
Junde Han, Lingqi Gao, Jing Dong, Jie Bai, Mazhong Zhang, Jijian Zheng
Published: 20 July 2017 [Full Text]

Physical disruption of cell–cell contact induces VEGF expression in RPE cells
Farhad Farjood, Elizabeth Vargis
Published: 17 July 2017 [Full Text]

Origins of the phototransduction delay as inferred from stochastic and deterministic simulation of the amplification cascade
Alexander Yu Rotov, Luba A. Astakhova, Michael L. Firsov, Victor I. Govardovskii
Published: 07 July 2017 [Full Text]

Using MALDI-TOF-MS to test Staphylococcus aureus–infected vitreous
Zhenyu Song, Xiuping Liu, Minyu Zhu, Yiwei Tan, Kaili Wu
Published: 07 July 2017 [Full Text]

Genome-wide retinal transcriptome analysis of endotoxin-induced uveitis in mice with next-generation sequencing
Yiguo Qiu, Peng Yu, Ru Lin, Xinyu Fu, Bingtao Hao, Bo Lei
Published: 03 July 2017 [Full Text]

Genistein suppresses retinoblastoma cell viability and growth and induces apoptosis by upregulating miR-145 and inhibiting its target ABCE1
Dong Wei, Lieying Yang, Bo Lv, Lijuan Chen
Published: 03 July 2017 [Full Text]

Comparison of two neurotrophic serpins reveals a small fragment with cell survival activity
Paige N. Winokur, Preeti Subramanian, Jeanee L. Bullock, Veronique Arocas, S. Patricia Becerra
Published: 03 July 2017 [Full Text]

The presence of kynurenine aminotransferases in the human cornea: Evidence from bioinformatics analysis of gene expression and immunohistochemical staining
Anna Matysik-Woźniak, Anselm Jünemann, Waldemar A. Turski, Artur Wnorowski, Krzysztof Jóźwiak, Roman Paduch, Etsuo Okuno, Joanna Moneta-Wielgoś, Tomasz Chorągiewicz, Ryszard Maciejewski, Robert Rejdak
Published: 26 June 2017 [Full Text]

Pro- and antiangiogenic VEGF and its receptor status for the severity of diabetic retinopathy
Suman K. Paine, Lakshmi K. Mondal, Prasanta K. Borah, Chandra K. Bhattacharya, Jagadish Mahanta
Published: 22 June 2017 [Full Text]

Cedilanid inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
Jing Shang Zhang, Jin Da Wang, Ying An, Ying Xiong, Jing Li, JostB. Jonas, Liang Xu, Wei Zhang, Xiu Hua Wan
Published: 16 June 2017 [Full Text]

Meclofenamic acid improves the signal to noise ratio for visual responses produced by ectopic expression of human rod opsin
Cyril G. Eleftheriou, Jasmina Cehajic-Kapetanovic, Franck P. Martial, Nina Milosavljevic, Robert A. Bedford, Robert J. Lucas
Published: 16 June 2017 [Full Text]

Specific correlation between the major chromosome 10q26 haplotype conferring risk for age-related macular degeneration and the expression of HTRA1
Sha-Mei Liao, Wei Zheng, Jiang Zhu, Casey A. Lewis, Omar Delgado, Maura A. Crowley, Natasha M. Buchanan, Bruce D. Jaffee, Thaddeus P. Dryja
Published: 14 June 2017 [Full Text]

A dot hybridization assay for the diagnosis of bacterial keratitis
Po-Chiung Fang, Chun-Chih Chien, Hun-Ju Yu, Ren-Wen Ho, Shin-Ling Tseng, Yu-Hsuan Lai, Ming-Tse Kuo
Published: 28 April 2017 [Full Text]

Identification of seven novel ZNF469 mutations in keratoconus patients in a Han Chinese population
Xiaoning Yu, Binbin Chen, Xin Zhang, Xingchao Shentu
Published: 28 April 2017 [Full Text]

Inhibitory effects of S100A4 gene silencing on alkali burn-induced corneal neovascularization: an in vivo study
Yu-Lin Wang, Gui-Ping Gao, Yu-Qin Wang, Ying Wu, Zhi-You Peng, Quan Zhou
Published: 26 April 2017 [Full Text]

Comparison of fibrin glue and Vicryl sutures in conjunctival autografting for pterygium surgery
Xiu Wang, Yan Zhang, Lei Zhou, Ruihua Wei, Lijie Dong
Published: 19 April 2017 [Full Text]

Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome
Kishore Kumar Godisela, Singareddy Sreenivasa Reddy, Chekkilla Uday Kumar, Natarajan Saravanan, Paduru Yadagiri Reddy, Monica M. Jablonski, Radha Ayyagari, Geereddy Bhanuprakash Reddy
Published: 14 April 2017 [Full Text]

The MicroRNA-21 signaling pathway is involved in prorenin receptor (PRR) –induced VEGF expression in ARPE-19 cells under a hyperglycemic condition
Rashidul Haque, P. Michael Iuvone, Li He, Kimberly Su Chung Choi, Ashley Ngo, Samantha Gokhale, Madiha Aseem, Daniel Park
Published: 14 April 2017 [Full Text]

Resolvin D1 inhibits inflammatory response in STZ-induced diabetic retinopathy rats: Possible involvement of NLRP3 inflammasome and NF-κB signaling pathway
Yizhou Yin, Fei Chen, Wenyan Wang, Han Wang, Xuedong Zhang
Published: 14 April 2017 [Full Text]

Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7
Youwen Zhang, Samuel D. Cross, James B. Stanton, Alan D. Marmorstein, Yun Zheng Le, Lihua Y. Marmorstein
Published: 14 April 2017 [Full Text]

UVB promotes the initiation of uveitic inflammatory injury in vivo and is attenuated by UV-blocking protection
Yi-Ching Shao, Jyh-Cheng Liou, Chan-Yen Kuo, Yun-Shan Tsai, En-Chieh Lin, Ching-Ju Hsieh, Si-Ping Lin, Bo-Yie Chen
Published: 12 April 2017 [Full Text]

Complement C5a receptor knockout has diminished light-induced microglia/macrophage retinal migration
Delu Song, Michael E. Sulewski, Chenguang Wang, Jiantao Song, Rupak Bhuyan, Jacob Sterling, Esther Clark, Wen-Chao Song, Joshua L. Dunaief
Published: 10 April 2017 [Full Text]

Cone dystrophy or macular dystrophy associated with novel autosomal dominant GUCA1A mutations
Gaël Manes, Sonia Mamouni, Emilie Hérald, Anne-Claire Richard, Audrey Sénéchal, Karim Aouad, Béatrice Bocquet, Isabelle Meunier, Christian P. Hamel
Published: 03 April 2017 [Full Text]

Serum retinol-binding protein-induced endothelial inflammation is mediated through the activation of toll-like receptor 4
Mei Du, Ashley Martin, Franklin Hays, Jennifer Johnson, Rafal A. Farjo, Krysten M. Farjo
Published: 31 March 2017 [Full Text]

LADD syndrome with glaucoma is caused by a novel gene
Allie Simpson, Armin Avdic, Ben R. Roos, Adam DeLuca, Kathy Miller, Michael J. Schnieders, Todd E. Scheetz, Wallace L.M. Alward, John H. Fingert
Published: 30 March 2017 [Full Text]

Intraperitoneal injection of (−)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina
Shounan Qi, Chenguang Wang, Delu Song, Ying Song, Joshua L. Dunaief
Published: 24 March 2017 [Full Text]

Knock-in of Cx46 partially rescues fiber defects in lenses lacking Cx50
Eddie Wang, Andrew Geng, Richard Seo, Ankur Maniar, Xiaohua Gong
Published: 24 March 2017 [Full Text]

Epigenetic intervention with a BET inhibitor ameliorates acute retinal ganglion cell death in mice
Jun Li, Lei Zhao, Go Urabe, Yingmei Fu, Lian-Wang Guo
Published: 21 March 2017 [Full Text]

A mutagenesis-derived Lrp5 mouse mutant with abnormal retinal vasculature and low bone mineral density
Jeremy R. Charette, Sarah E. Earp, Brent A. Bell, Cheryl L. Ackert-Bicknell, Dana A. Godfrey, Sujata Rao, Bela Anand-Apte, Patsy M. Nishina, Neal S. Peachey
Published: 18 March 2017 [Full Text]

Novel splice-site mutation in TTLL5 causes cone dystrophy in a consanguineous family
Miguel de Sousa Dias, Christian P. Hamel, Isabelle Meunier, Juliette Varin, Steven Blanchard, Fiona Boyard, José-Alain Sahel, Christina Zeitz
Published: 18 April 2017 [Full Text]

Osmotic regulation of NFAT5 expression in RPE cells: The involvement of purinergic receptor signaling
Margrit Hollborn, Sarah Fischer, Heidrun Kuhrt, Peter Wiedemann, Andreas Bringmann, Leon Kohen
Published: 18 March 2017 [Full Text]

Differential responses of choroidal melanocytes and uveal melanoma cells to low oxygen conditions
Cindy Weidmann, Jade Pomerleau, Laurence Trudel-Vandal, Solange Landreville
Published: 12 March 2017 [Full Text]

Reduced phosphoCREB in Müller glia during retinal degeneration in rd10 mice
Enheng Dong, Amelia Bachleda, Yubin Xiong, Shoji Osawa, Ellen R. Weiss
Published: 08 March 2017 [Full Text]

Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells
William Samuel, Cynthia Jaworski, Olga. A. Postnikova, R. Krishnan Kutty, Todd Duncan, Li Xuan Tan, Eugenia Poliakov, Aparna Lakkaraju, T. Michael Redmond
Published: 05 March 2017 [Full Text]

The involvement of ATF4 and S-opsin in retinal photoreceptor cell damage induced by blue LED light
Emi Ooe, Kazuhiro Tsuruma, Yoshiki Kuse, Saori Kobayashi, Masamitsu Shimazawa, Hideaki Hara
Published: 05 March 2017 [Full Text]

EBM regeneration and changes in EBM component mRNA expression in stromal cells after corneal injury
Abirami Santhanam, Gustavo K. Marino, Andre A. M. Torricelli, Steven E. Wilson
Published: 26 February 2017 [Full Text]

Zinc oxide tetrapods inhibit herpes simplex virus infection of cultured corneas
Neil Duggal, Dinesh Jaishankar, Tejabhiram Yadavalli, Satvik Hadigal, Yogendra Kumar Mishra, Rainer Adelung, Deepak Shukla
Published: 26 February 2017 [Full Text]

Mertk gene expression and photoreceptor outer segment phagocytosis by cultured rat bone marrow mesenchymal stem cells
Rong-mei Peng, Jing Hong, Ying Jin, Yu-zhao Sun, Yi-qian Sun, Pei Zhang
Published: 28 January 2017 [Full Text]

Study of polymorphisms in the TP53 and RB1 genes in children with retinoblastoma in northern Mexico
Edwin J. Anaya-Pava, Jesús Nares-Cisneros, Rubén I. Cárdenas-Hernández, Yolanda Jaramillo-Rodríguez, Graciela Zambrano-Galván
Published: 28 January 2017 [Full Text]

Epac1 agonist decreased inflammatory proteins in retinal endothelial cells, and loss of Epac1 increased inflammatory proteins in the retinal vasculature of mice
Li Liu, Youde Jiang, Adam Chahine, Elizabeth Curtiss, Jena J. Steinle
Published: 25 January 2017 [Full Text]


Archive Volumes 1-22 (1995-2016)

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