Table 2 of
Mukhopadhyay, Mol Vis 2002;
8:271-279.
Table 2. Sequence alignments of proteins with homology to human myocilin
Segments of N-terminal and C-terminal regions of human myocilin are shown with overlapping regions of other proteins in A and B, respectively. In C, the homologous segments of human myocilin and Xenopus noelin are shown. Co-ordinates (amino acid numbers) of the region of each protein are indicated on both sides of the amino acid sequence. The sequences were aligned by eye to maximize amino acid identities. Human myocilin was the reference protein used as query. Locations where amino acids are identical are marked by a caret (^). Locations where any change is restricted to conservative amino acids are marked by asterisk (*), and locations where the amino acids are conserved in all but one species are marked by a plus sign (+). Putative sequence motifs are colored: green for PKC, blue for CK2, and red for N-myristoylation. Overlap between two putative sites have been shown by a purple marker. For example, in B TGKE residues represent an overlapping PKC (TGK) and a CK2 (TGKE) site. Among all the proteins mentioned in Figure 2, only the leucine zipper motifs for myocilin are present in the homologous region presented in this table (from amino acids 116-166).
A
Species Protein Segments with homology to human myocilin --------------- -------------- ----------------------------------------------------------------------- S. pyogenes M3 Protein 383 GLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKA 443 D. discoideum Myosin HC 965 GQSDTISRLEKIKDELQKEVEELTESFSEESKDKGVLEKTRVRLQSELDDLTVRLDSETKD 1025 D. melanogaster Myosin HC-like 1233 GTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQ 1293 H. sapiens Myocilin 116 GLQRELGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQE 176 ^ * ++ * + ^ ^^ + ++ + + + |
B
Species Protein Segments with homology to human myocilin --------------- ----------------- -------------------------------------------------------------------------- C. elegans Olfactomedin-like 460 LYDRPHNYVDFAVDENGLWAIYAG-ADSETMRMAKIEP-SLFVVNIWNVEVNTTEIADSFIMCGV 522 D. melanogaster CG6867 796 LYTTDYNYMDFNVDEVGLWVIYSTYNSN-NTLVAKLDAETLKMQYNFNITLDHHQFGEMFIVCGN 859 R. catesbeiana Olfactomedin 332 YAGTMFQDMDFSSDEKGLWVIFTTEKSAGKIVVGKVNVATFTVDNIWITTQNKSDASNAFMICGV 396 H. sapiens Myocilin 372 YSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGT 435 * *^* +^^ ^^^+^+ + * ^* * *+ * * + * ^+*^^ C. elegans Olfactomedin-like 523 WYGLKSANNLQTQITHAYDLFRNDTIPGQVEWYNPYQGLTMLGYNPLDARLYFFDNSSLLSVNVRI 588 D. melanogaster CG6867 860 LYAIDSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIRY 925 R. catesbeiana Olfactomedin 397 LYVTRSLGPKMEEVFYMFDTKTGKEGHLSIMMEKMAEKVHSLSYNSNDRKLYMFSEGYLLHYDIAL 462 H. sapiens Myocilin 436 LYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKL 501 +^ ^ * * * ^ + ** * + * ^^++ ^ *+ *** + + |
C
Species Protein Segments with homology to human myocilin ---------- -------- -------------------------------------------------------------------------- X. laevis Noelin-1 87 RDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVERMENQMKGLESKFKQVEETHRQHQARQFK 152 H. sapiens Myocilin 128 RDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQ---ENENLARRLESSSQEVARL-RRGQCPQTR 189 ^^ ^ ^ ^* *^* ^^* ^ ^ ^^ ** ^^^ ^ ^ ^ ^ * X. laevis Noelin-1 153 AIKAKMEELRPLIPVLEEYKADAKLVLQFKEEIQNLTSVLNE-LQEEIGAYDYEELQSRVSNLEER 217 H. sapiens Myocilin 190 ------DTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGY-------------- 248 * *^***^ ^ ^ ^ ^ * ^^ ^* * ^ * X. laevis Noelin-1 218 LRACMQKLACGKLTGISEPVTIKTSGS---RFGSWMTD--PLAPEGDNRVWYMDGYHNN-RFVREY 277 H. sapiens Myocilin 249 LRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEY 301 ^^ * * ^^ ^ **^^*^**^ * * ^ ^^ ^ ^ ^ * ^ *^* * ^ ^ ^^ X. laevis Noelin-1 278 KSMEDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKSETILKTRSLDSAGYTN 343 H. sapiens Myocilin 302 DLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHG 367 * ^^** ^ ^^*^* *^^ ^^^*^^*^^ * *^* *^^ *^ *^^* * * *^^^ * X. laevis Noelin-1 344 VYHYAWGGQSDIDLMVDENGLWVVYATNQNAGNIVISKLDPNTLQILKTWNTGYPKRSAGEAFMIC 409 H. sapiens Myocilin 368 QFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIIC 433 ^ ^^^**^^^^*^^^ ^^^^*^ ^ ^ ^^*^^^ ^ *^ * ^^ ^* ^ ^* ^^*^^ X. laevis Noelin-1 410 GTLYVTNGY-SGGTKVHYAYQTNTSNYEYIDIPFHNLYSHISMLDYNPKDRALYAWNNGHQILYNV 474 H. sapiens Myocilin 434 GTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDI 499 ^^^^ **^ ^ ^ ^^ ^*^* * ** ^^^*^ ^ ^^*^^^^ ** ^ ^^ ^ * ^ * X. laevis Noelin-1 475 TL 476 H. sapiens Myocilin 500 KL 501 ^ |