Table 2 of Mukhopadhyay, Mol Vis 2002; 8:271-279.


Table 2. Sequence alignments of proteins with homology to human myocilin

Segments of N-terminal and C-terminal regions of human myocilin are shown with overlapping regions of other proteins in A and B, respectively. In C, the homologous segments of human myocilin and Xenopus noelin are shown. Co-ordinates (amino acid numbers) of the region of each protein are indicated on both sides of the amino acid sequence. The sequences were aligned by eye to maximize amino acid identities. Human myocilin was the reference protein used as query. Locations where amino acids are identical are marked by a caret (^). Locations where any change is restricted to conservative amino acids are marked by asterisk (*), and locations where the amino acids are conserved in all but one species are marked by a plus sign (+). Putative sequence motifs are colored: green for PKC, blue for CK2, and red for N-myristoylation. Overlap between two putative sites have been shown by a purple marker. For example, in B TGKE residues represent an overlapping PKC (TGK) and a CK2 (TGKE) site. Among all the proteins mentioned in Figure 2, only the leucine zipper motifs for myocilin are present in the homologous region presented in this table (from amino acids 116-166).

A

    Species          Protein                      Segments with homology to human myocilin
---------------   --------------   -----------------------------------------------------------------------

S. pyogenes       M3 Protein        383 GLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKA  443
D. discoideum     Myosin HC         965 GQSDTISRLEKIKDELQKEVEELTESFSEESKDKGVLEKTRVRLQSELDDLTVRLDSETKD 1025
D. melanogaster   Myosin HC-like   1233 GTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQ 1293
H. sapiens        Myocilin          116 GLQRELGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQE  176
                                        ^    * ++   *   +    ^              ^^  + ++  +   +   +

B

    Species            Protein                         Segments with homology to human myocilin
---------------   -----------------   --------------------------------------------------------------------------

C. elegans        Olfactomedin-like   460 LYDRPHNYVDFAVDENGLWAIYAG-ADSETMRMAKIEP-SLFVVNIWNVEVNTTEIADSFIMCGV  522
D. melanogaster   CG6867              796 LYTTDYNYMDFNVDEVGLWVIYSTYNSN-NTLVAKLDAETLKMQYNFNITLDHHQFGEMFIVCGN  859
R. catesbeiana    Olfactomedin        332 YAGTMFQDMDFSSDEKGLWVIFTTEKSAGKIVVGKVNVATFTVDNIWITTQNKSDASNAFMICGV  396
H. sapiens        Myocilin            372 YSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGT  435
                                                * *^* +^^ ^^^+^+ +        * ^* * *+ * * +        *   ^+*^^

C. elegans        Olfactomedin-like   523 WYGLKSANNLQTQITHAYDLFRNDTIPGQVEWYNPYQGLTMLGYNPLDARLYFFDNSSLLSVNVRI 588
D. melanogaster   CG6867              860 LYAIDSGTDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIRY 925
R. catesbeiana    Olfactomedin        397 LYVTRSLGPKMEEVFYMFDTKTGKEGHLSIMMEKMAEKVHSLSYNSNDRKLYMFSEGYLLHYDIAL 462
H. sapiens        Myocilin            436 LYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKL 501
                                          +^   ^ *     *  * ^   +     ** * +       * ^^++   ^  *+  *** + +

C

 Species     Protein                     Segments with homology to human myocilin
----------   --------   --------------------------------------------------------------------------

X. laevis    Noelin-1    87 RDARTKQLRQLLEKVQNMSQSIEVLDRRTQRDLQYVERMENQMKGLESKFKQVEETHRQHQARQFK 152
H. sapiens   Myocilin   128 RDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQ---ENENLARRLESSSQEVARL-RRGQCPQTR 189
                            ^^    ^ ^ ^*   *^*     ^^*    ^  ^     ^^ ** ^^^    ^    ^  ^  ^ *

X. laevis    Noelin-1   153 AIKAKMEELRPLIPVLEEYKADAKLVLQFKEEIQNLTSVLNE-LQEEIGAYDYEELQSRVSNLEER 217
H. sapiens   Myocilin   190 ------DTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGY-------------- 248
                                  * *^***^   ^        ^ ^ ^  * ^^ ^*   *  ^   *

X. laevis    Noelin-1   218 LRACMQKLACGKLTGISEPVTIKTSGS---RFGSWMTD--PLAPEGDNRVWYMDGYHNN-RFVREY 277
H. sapiens   Myocilin   249 LRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEY 301
                            ^^ * *   ^^ ^  **^^*^**^  *   * ^ ^^ ^  ^  ^ *    ^ *^*  *  ^ ^ ^^

X. laevis    Noelin-1   278 KSMEDFMNTDNFTSHRLPHPWSGTGQVVYNGSIYFNKFQSHIIIRFDLKSETILKTRSLDSAGYTN 343
H. sapiens   Myocilin   302 DLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHG 367
                              *  ^^**     ^ ^^*^* *^^ ^^^*^^*^^ * *^* *^^ *^ *^^*   * * *^^^ *

X. laevis    Noelin-1   344 VYHYAWGGQSDIDLMVDENGLWVVYATNQNAGNIVISKLDPNTLQILKTWNTGYPKRSAGEAFMIC 409
H. sapiens   Myocilin   368 QFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIIC 433
                               ^ ^^^**^^^^*^^^ ^^^^*^ ^    ^ ^^*^^^ ^ *^ *  ^^ ^*  ^ ^*  ^^*^^

X. laevis    Noelin-1   410 GTLYVTNGY-SGGTKVHYAYQTNTSNYEYIDIPFHNLYSHISMLDYNPKDRALYAWNNGHQILYNV 474
H. sapiens   Myocilin   434 GTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDI 499
                            ^^^^  **^ ^    ^  ^^ ^*^* * ** ^^^*^ ^   ^^*^^^^ ** ^ ^^ ^   * ^ *

X. laevis    Noelin-1   475 TL 476
H. sapiens   Myocilin   500 KL 501
                             ^

Mukhopadhyay, Mol Vis 2002; 8:271-279 <http://www.molvis.org/molvis/v8/a34/>
©2002 Molecular Vision <http://www.molvis.org/molvis/>
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