Figure 2 of
Mukhopadhyay, Mol Vis 2002;
Figure 2. Protein sequences which share significant sequence homology with human myocilin
Human myocilin sequence was used as query and homology search was done using BLASTp program at the NCBI server as described in the Methods section. Regions of the proteins (identified in Table 1) bearing homology to human myocilin is shown by bar diagrams, depending on the level of homology, as indicated by a score (in arbitrary units). Relative locations of sequence motifs with putative functions are marked. The S. pyogenes protein, which contains sequences that match the motif for protein kinase C (PKC) phosphorylation sites, have not been shown because bacteria do not have PKC. The genomic structure of myocilin gene (i.e. exon boundaries) is shown with respect to the encoded protein. Exon 2 approximately corresponds to the region that does not have homology to non-myocilin proteins in lower organisms, and have not yet been associated to any among 34 characterized mutations to date causal to primary open angle glaucoma.