Table 1 of
Mukhopadhyay, Mol Vis 2002;
8:271-279.Table 1 of
Mukhopadhyay, Mol Vis 2002;
8:271-279.
Table 1. Proteins in non-mammalian species with homology to human myocilin
Regions of human myocilin (NP_000252) bearing homology to the protein in other species are indicated by amino acid numbers of myocilin. Number (and percentage) of amino acids that are identical to human myocilin within the homologous segment is given. The homology search between proteins by BLASTp provides the E value ("expect" value) which is an estimation of the probability of finding the homology by chance. Hence, the lower the E value, the higher the significance of homology.
Region of
Protein Length myocilin
accession of bearing
Name of protein number Source E value protein homology Identity
----------------------------- --------- --------------- ------- ------- --------- ------------
Proteins with homology to
N-terminal region of myocilin
M3 Protein AAA96960 S. pyogenes 5e-05 539 aa 84-196 38/129 (29%)
Myosin heavy chain AAA33227 D. discoideum 9e-05 2116 aa 58-222 36/168 (21%)
Myosin-heavy-chain-like AAF55271 D. melanogaster 8e-04 1706 aa 74-176 27/103 (26%)
Dynactin 1 P35458 G. gallus 5e-05 1224 aa 50-181 40/141 (28%)
Proteins with homology to
C-terminal region of myocilin
Olfactomedin-like CAB04088 C. elegans 1e-23 598 aa 260-503 71/262 (27%)
CG6867 AAF48788 D. melanogaster 2e-28 935 aa 251-503 74/254 (29%)
Olfactomedin AAA49527 R. catesbeiana 2e-20 464 aa 323-501 56/179 (31%)
Proteins with homology to
both N- & C-terminal regions
of myocilin
Noelin-1 AAL66227 X. laevis 3e-57 485 aa 128-501 138/399 (34%)
Neuronal olfactomedin-related AAF40413 G. gallus 5e-60 485 aa 110-501 134/407 (32%)
ER localized protein
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