Figure 5 of
Wistow, Mol Vis 2002;
8:185-195.Figure 5 of
Wistow, Mol Vis 2002;
8:185-195.
Figure 5. Sequence of human Ris
A: The complete sequence of clone bx05f09. The predicted amino acid sequence is shown. The GTP binding motif is shown in red and the rest of the Ras-family signature in blue. The polyadenylation signal is shown in green. B: Cartoon of Ris gene structure. Exons are boxed and coding sequence is shown in red.
A
GTCCGGGGCCGCGCGCTCCAGGGAAGCCTGCATCCCGCTCCCCTGGGCCCCGACGGGCGG 60
M 1
GCGCACTGCGCGGGGCCCACCGGCCGCAGACCTGCGTGGCCGTCCAGGGCGTCGCCATGT 120
S S V F G K P R A G S G P Q S A P L E V 21
CCTCGGTGTTTGGAAAACCCCGCGCGGGCAGCGGGCCTCAGAGCGCGCCCCTCGAGGTCA 180
N L A I L G R R G A G K S A L T V K F L 41
ACCTGGCCATCCTGGGGCGCCGCGGGGCTGGCAAGTCTGCCCTGACCGTGAAGTTTCTGA 240
T K R F I S E Y D P N L E D T Y S S E E 61
CCAAGAGGTTTATCAGTGAATATGACCCCAACTTGGAGGACACCTACAGCTCCGAGGAGA 300
T V D H Q P V H L R V M D T A D L D T P 81
CTGTGGACCACCAGCCTGTCCACCTGAGGGTCATGGACACTGCAGACCTGGACACCCCCA 360
R N C E R Y L N W A H A F L V V Y S V D 101
GGAACTGCGAGCGCTACCTGAACTGGGCCCATGCCTTCCTGGTGGTGTACAGCGTCGACA 420
S R Q S F D S S S S Y L E L L A L H A K 121
GCCGCCAGAGCTTTGATAGCAGCAGCAGCTACCTGGAGCTGCTTGCCTTGCACGCGAAGG 480
E T Q R S I P A L L L G N K L D M A Q Y 141
AGACACAGCGCAGCATCCCTGCCCTGCTGCTGGGCAACAAGCTGGACATGGCTCAGTACA 540
R Q V T K A E G V A L A G R F G C L F F 161
GGCAAGTCACCAAGGCAGAGGGTGTGGCTTTGGCAGGCAGGTTTGGGTGCCTGTTTTTCG 600
E V S A C L D F E H V Q H V F H E A V R 181
AGGTCTCTGCCTGTCTGGACTTTGAGCACGTGCAGCATGTCTTCCACGAGGCAGTGCGAG 660
E A R R E L E K S P L T R P L F I S E E 201
AGGCACGGCGGGAGCTGGAGAAGAGCCCCCTGACCCGGCCCCTCTTCATCTCCGAGGAGA 720
R A L P H Q A P L T A R H G L A S C T F 221
GGGCCCTGCCCCACCAGGCCCCGCTCACCGCGCGGCATGGGCTGGCCAGCTGCACCTTCA 780
N T L S T I N L K E M P T V A Q A K L V 241
ACACGCTCTCCACCATCAACCTGAAGGAGATGCCCACTGTGGCCCAGGCCAAGCTGGTCA 840
T V K S S R A Q S K R K A P T L T L L K 261
CCGTGAAGTCATCCCGGGCCCAGAGCAAGCGCAAGGCGCCTACCCTGACTCTCCTGAAGG 900
G F K I F * 266
GCTTCAAGATCTTCTGAGGCCCCCTCCCCAGGAAGCCTAGGCTCGGTGGCTGGACAGGAC 960
TGCAGCAGGACAGGGACTGGCTTCTCACCACCAGCCTTTCCGTCTGATGGACAGCAGACC 1020
CCGCCTCCAGCACCAAGCAGTGTCCCTACACTCAATTCACTGTGTGAGCTGGAGTGGCAG 1080
GCAGGGATGCTGCTTCTGTTCCCTCCAGGCCTTGGTCTTCATGGTAACCACCGCGTCTGT 1140
GGCCGTAGAGGGAAACAGCCACTGTGACAACCCAGAGACCTGGGGTCAGCCTTAAGTAGG 1200
AAGAAATTGCAGTGTCTATCCTGCTGCCATCAGCCCTTCCTGCTCCAGCTACAGTTGGGC 1260
CAGCTGTGGCCTTAGTGGATGGTCTGGGTGGATGGCTCTGTCAATGTCAGGCCCGAGAAC 1320
AGCCTGCGGAATGACAGCCTGGGGTCCTTGTGCCACCTGGTGGACGGGAAAGGCAGGCGG 1380
CTGCAGTTTCAGAGGCCAGAGCCTGGCCCTCCTGTCATCTGCTGACTTCACAGAAGGCCC 1440
AGGCTACAAACCCCACAGTTTATCAAGGAAAATCTAGTTAAAATAATCCAATGGACAGAA 1500
GCCCCAGGAAGGGGTATTTCCAACACTTGGCGTCTCAATGAGGATAAAAGGGAGGGACTG 1560
TAGGTTGTCCAGCATAAGGAGCCCCAGAGTTCTTTCACCAGCAGACAGATTCTCCATGTG 1620
TTTTCCCACTGTTAAGGACTCTGTCCAAAGAACCTCAGCATCAGCTCCCTCAAGCTTAAT 1680
GATCCAGGCTGCAGAAGAAAGTTGTCACTCCAGTGAGTTACCCAGGGCTCCAGGGAGCCC 1740
ACAGCAGCATCAGACCCATCCAGGGGCTACAGGGCCTGCCCCCCTGCAGGTAGAAACACA 1800
GTATACCCGTTTGTCATCTGGTTTGGCAGGACCCAGGACCCTCAGCAATGAGTCTGAGTG 1860
TTCAAAGCCCACTTTAGAACCTAAAGCATTTTGGGTTAATAAAGCAAAATTTTGCTTATG 1920
TTATTTGGTGGTGTCACCGCAGCTTATACCAAGACACCATGGCTCAGACATGGGATCAGG 1980
ACACACCTTTGAGATCCCACTGTTAGCAAGAAAAGGCTGTCCAAGGCAGGCAGTGTGGTA 2040
GTTGTCTGATTTTGTTTACCACACGCCAGGTCCCAGGGAAGTCTTGCACAGACTCTTAGC 2100
AGACAAGCAGGGAAAAGAGAGGGTCCTGGTGGGTGGAAGGATTGGGAAGGGGATTCTGGG 2160
CCTGGAAGCCTGCTCCTTCCCCTCTCAGCCGTCTCAGGACTACTGTTGGATTGCAAACAG 2220
CATCTCTGACCCAGTCTTCGGACTCATTCTGTAAATGGAGGAGCTGAGGTCAGAGGGGGG 2280
CTGTGAACTACTCAAGACCACATGCTTGCAGTCCTACAGGCTTCCCGACCCACAGGCCAG 2340
CTACGGATTTTGCACTTTTGCTCCAGGCCACTTGTGTGTGTATGTGTGTGTGTACCACTG 2400
CCATCTGAACAAACTATGCAATACCACCTGCTCCCTTCCAGGAGCATTTTAATAAAAGAT 2460
TTTTTTTAATAACAGAAAAAAAAAAAAAAAAAAAAAAAAA 2500
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B
