Table 1 of
Marcus, Mol Vis 2000;
6:169-177.Table 1 of
Marcus, Mol Vis 2000;
6:169-177.
Table 1. Light and electron microscopic findings in APC 1638 and Wild-Type Mice
By light microscopy, 4 of 38 APC 1638 eyes demonstrated focal RPE atrophy and increased melanasome production. One embryonic eye, one 1-month old eye, and one 6-month old eye from APC 1638 mice demonstrated RPE hyperplasia. Wild type mice demonstrated no abnormalities by light microscopy. Notated animals and eyes were examined by electroretinography and electron microscopy, respectively.
APC 1638 Mice
Ocular Findings
Mouse -------------------------------------------------------
number Age Right Eye Left Eye
------ -------- -------------------------- --------------------------
1 E18 days Normal Normal
2 E18 days Normal Normal
3 E18 days Normal Focal RPE hyperplasia*
4 E18 days Normal Normal
5 1 month Normal Normal
6 1 month Normal Normal
7 1 month RPE Hyperplasia and focal Normal*
RPE atrophy with
increased melanosome
production*
8 2 months Normal Normal
9 2 months Tissue Not Available Focal RPE atrophy with
increased melanosome
production*
10 2 months Normal Normal
11 3 months Normal* Normal
12 3 months Normal* Normal
13 3 months Normal* Focal RPE atrophy with
increased melanosome
production*
14 4 months Normal Normal
15 4 months Normal* Normal*
16 4 months Normal Normal
17 6 months Traumatic Perforation** Normal***
18 6 months Minimal Focal** Normal***
Peripapillary RPE
Hyperplasia
19 6 months Not Studied Normal**
20 6 months Focal RPE atrophy with Normal***
increased melanosome
production **
Wild-Type Mice
Ocular Findings
Mouse -------------------------------------------------------
number Age Right Eye Left Eye
------ -------- -------------------------- --------------------------
1 E18 days Normal* Normal
2 E18 days Normal Normal
3 E18 days Normal Normal
4 E18 days Normal Normal
5 1 month Normal* Normal
6 2 months Normal* Normal
7 3 months Normal Normal*
8 4 months Normal Normal*
9 6 months Normal** Normal***
10 6 months Normal** Normal***
11 6 months Normal** Normal**
E18 days = Embryonic day 18
RPE = Retinal Pigment Epithelium
* Transmission electron microscopy
** ERG at 5-26 weeks of age
*** ERG at 26 weeks of age
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