Table 1 of
Marcus, Mol Vis 2000;
6:169-177.
Table 1. Light and electron microscopic findings in APC 1638 and Wild-Type Mice
By light microscopy, 4 of 38 APC 1638 eyes demonstrated focal RPE atrophy and increased melanasome production. One embryonic eye, one 1-month old eye, and one 6-month old eye from APC 1638 mice demonstrated RPE hyperplasia. Wild type mice demonstrated no abnormalities by light microscopy. Notated animals and eyes were examined by electroretinography and electron microscopy, respectively.
APC 1638 Mice Ocular Findings Mouse ------------------------------------------------------- number Age Right Eye Left Eye ------ -------- -------------------------- -------------------------- 1 E18 days Normal Normal 2 E18 days Normal Normal 3 E18 days Normal Focal RPE hyperplasia* 4 E18 days Normal Normal 5 1 month Normal Normal 6 1 month Normal Normal 7 1 month RPE Hyperplasia and focal Normal* RPE atrophy with increased melanosome production* 8 2 months Normal Normal 9 2 months Tissue Not Available Focal RPE atrophy with increased melanosome production* 10 2 months Normal Normal 11 3 months Normal* Normal 12 3 months Normal* Normal 13 3 months Normal* Focal RPE atrophy with increased melanosome production* 14 4 months Normal Normal 15 4 months Normal* Normal* 16 4 months Normal Normal 17 6 months Traumatic Perforation** Normal*** 18 6 months Minimal Focal** Normal*** Peripapillary RPE Hyperplasia 19 6 months Not Studied Normal** 20 6 months Focal RPE atrophy with Normal*** increased melanosome production ** Wild-Type Mice Ocular Findings Mouse ------------------------------------------------------- number Age Right Eye Left Eye ------ -------- -------------------------- -------------------------- 1 E18 days Normal* Normal 2 E18 days Normal Normal 3 E18 days Normal Normal 4 E18 days Normal Normal 5 1 month Normal* Normal 6 2 months Normal* Normal 7 3 months Normal Normal* 8 4 months Normal Normal* 9 6 months Normal** Normal*** 10 6 months Normal** Normal*** 11 6 months Normal** Normal** E18 days = Embryonic day 18 RPE = Retinal Pigment Epithelium * Transmission electron microscopy ** ERG at 5-26 weeks of age *** ERG at 26 weeks of age |