Figure 8. Locations of predicted protein modification sites and mutations on TIGR/MYOC protein

Location of 33 published TIGR/MYOC mutations superimposed on GOR (upper) and CF (lower) predictions for TIGR/MYOC. Mutations in red text are from pedigrees where the mean age at onset is under 35 years of age. Boxed mutations have been reported to co-segregate with glaucoma. Individual groups that published each mutation are shown in the key. Predicted protein modification motifs identified from Prosite and secondary structure predictions are defined in the key and correspond to the legend in Figure 7.