Table 2 of Uren, Mol Vis 2014; 20:1612-1628.

Table 2. Most significant expression changes in rd10 transcriptome.

Gene Direction WT RPKM rd10 RPKM Function Implicated in RP
Prph2 (Retinal degeneration slow) Down 2310.8 75.9 Disc morphogenesis Evidence [108]
Fscn2 Down 90.8 0.7 Disc morphogenesis Evidence [109]
Guca1b (RP48) Down 651.8 6.6 Photoresponse [110] Evidence [111]
Serpina3n Up 2.7 76.4 Inflammation Evidence [112]
Reep6 Down 1143.8 31.2 Unknown No evidence
Pde6g (Phosphodiesterase) Down 3971.3 117.6 Phototransduction Evidence [113]
Sag (Arrestin) Down 4121.9 192.8 Phototransduction Evidence [114]
Rho (Rhodopsin) Down 11,271.4 68.9 Phototransduction Evidence [115]
Pdc (Phosducin) Down 1479.1 42.0 Phototransduction [116] No evidence [117]
Ccdc24 Down 120.5 5.2 Unknown No evidence

Shown are the top ten most significant changes in gene expression between wild-type and rd10 retinas. RPKM values are means across all replicates. A direction of ‘up’ indicates increased relative expression in rd10 over wild-type, while ‘down’ indicates decreased relative expression in rd10 over wild-type.

Uren, Mol Vis 2014; 20:1612-1628. http://www.molvis.org/molvis/v20/1612

©2014 Molecular Vision http://www.molvis.org/molvis/

ISSN 1090-0535