Molecular Vision: Ma, Mol Vis 2014; 20:1434-1442. Table 2

Table 2. Meta-analysis of the association between SERPING1 gene and age-related macular degeneration.

Subgroup analysis	G allele versus A (Allele model)			GG + GA versus AA (Dominant model)			GG versus GA + AA (Recessive model)			GG versus AA (Homozygous model)			GG versus GA (Heterozygous model)
Subgroup analysis	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P	OR	95%CI	P
Overall	1.09	1.03–1.15	0.002	1.14	1.03–1.26	0.014	1.10	1.02–1.19	0.012	1.20	1.07–1.34	0.002	1.08	1.00–1.17	0.063
Ethnicity
Caucasians	1.09	1.03–1.15	0.001	1.14	1.02–1.26	0.017	1.12	1.03–1.21	0.008	1.19	1.06–1.34	0.003	1.09	1.00–1.19	0.046
Asians	1.03	0.85–1.24	0.755	1.25	0.61–2.53	0.541	1.02	0.82–1.25	0.874	1.25	0.61–2.54	0.543	1.00	0.81–1.24	0.983
Country
USA	1.21	1.05–1.41	0.010	1.19	0.90–1.57	0.223	1.37	1.10–1.70	0.005	1.42	1.04–1.93	0.028	1.35	1.07–1.71	0.010
UK	1.07	1.01–1.14	0.021	1.13	1.01–1.26	0.037	1.08	0.99–1.18	0.086	1.16	1.03–1.32	0.018	1.05	0.96–1.16	0.267
China	0.95	0.66–1.36	0.763	0.55	0.13–2.33	0.417	0.98	0.66–1.46	0.922	0.55	0.13–2.34	0.421	1.02	0.68–1.53	0.932
Japan	1.06	0.85–1.33	0.584	1.63	0.68–3.90	0.269	1.03	0.81–1.32	0.804	1.63	0.68–3.90	0.271	1.00	0.77–1.28	0.978
Source of control
Population-based	1.09	1.03–1.15	0.004	1.15	1.03–1.28	0.012	1.10	1.01–1.19	0.022	1.20	1.06–1.35	0.003	1.07	0.98–1.17	0.108
Hospital-based	1.08	0.92–1.25	0.345	1.04	0.74–1.47	0.822	1.11	0.92–1.34	0.285	1.19	0.81–1.74	0.373	1.10	0.90–1.35	0.335
Sample size
Small (n<300)	1.06	0.93–1.21	0.356	0.96	0.71–1.31	0.818	1.11	0.94–1.31	0.201	1.12	0.80–1.57	0.503	1.12	0.95–1.34	0.182
Large (n≥300)	1.09	1.03–1.16	0.003	1.16	1.04–1.30	0.007	1.10	1.01–1.20	0.029	1.21	1.07–1.36	0.002	1.07	0.97–1.17	0.162