Figure 9. Effects of γ-secretase inhibitor (GSI) on sCD44 normalized flow rate in perfusion cultured porcine anterior segments. Porcine anterior segments were perfused at constant pressure with 1 ng/ml sCD44 (as shown in Figure 7), 1 ng/ml CD44 + 15 mM GSI and 15 mM GSI alone. Time points are the mean ± SEM and the number of experiments are shown in the insert. The statistical comparisons are: sCD44 versus GSI alone, *p<0.05; sCD44vsCD44 +15mM GSI, † p<0.05, †† p<0.01. DMEM is Dulbecco’s Modified Eagle’s Medium.