Table 2 of
Chen, Mol Vis 2012; 18:816-829. Table 2 of
Chen, Mol Vis 2012; 18:816-829.
Table 2. Summary of allelic odds ratios of gene variants in polypoidal choroidal vasculopathy
| Gene/locus | SNP | Allele | PCV versus control OR (95% CI) | Case | Control | N | Ref | PCV versus AMD OR (95% CI) | N | Ref |
|---|---|---|---|---|---|---|---|---|---|---|
| LOC387715 | rs10490924 | T | 2.27 (1.84–2.79) | 2742 | 5383 | 9 | Figure 2A | 0.66 (0.57–0.76) | 5 | Figure 3A |
| HTRA1 | rs11200638 | A | 2.72 (2.04–3.63) | 864 | 1150 | 4 | Figure 2B | 0.86 (0.64–1.16) | 2 | Figure 3B |
| CFH | rs1061170 | C | 1.72 (1.42–2.10) | 1534 | 3950 | 4 | Figure 2C | 0.91 (0.71–1.18) | 2 | Figure 3C |
| CFH | rs800292 | G | 2.10 (1.87–2.37) | 2190 | 4138 | 5 | Figure 2D | 0.95 (0.79–1.16) | 2 | Figure 3D |
| CFH | rs3753394 | T | 2.12 (1.61–2.77) | 404 | 532 | 2 | Figure 2E | NA | ||
| CFH | rs1329428 | T | 1.74 (1.33–2.28) | 404 | 532 | 2 | Figure 2F | NA | ||
| CFH | rs1410996 | C | 1.82 (1.39–2.37) | 370 | 1082 | 2 | Figure 2G | 0.71 (0.47–1.06) | 1 | [22] |
| CFB | rs415667 | A | 0.79 (0.40–1.57) | 526 | 1288 | 3 | Figure 2H | 1.35 (0.38–4.73) | 1 | [22] |
| C2 | rs547154 | T | 0.56 (0.36–0.87) | 526 | 1288 | 3 | Figure 2I | 0.73 (0.26–2.10) | 1 | [22] |
| SERPING1 | rs2511989 | A | 0.97 (0.76–1.24) | 1256 | 898 | 2 | Figure 2J | 0.91 (0.70–1.20) | 1 | [37] |
| Elastin | rs2301995 | G | 1.17 (0.97–1.41) | 1644 | 1886 | 4 | Figure 2K | 1.07 (0.68–1.70) | 4 | Figure 3E |
| PEDF | rs1136287 | T | 0.99 (0.80–1.22) | 634 | 742 | 2 | Figure 2L | 1.07 (0.72–1.61) | 2 | Figure 3F |
| SOD2 | rs4880 | C | 0.81 (0.52–1.26) | 140 | 189 | 1 | [40] | 1.11 (0.66–1.88) | 1 | [40] |
| TLR3 | rs3775291 | T | 1.27 (0.93–1.73) | 120 | 274 | 1 | [41] | 1.16 (0.81–1.66) | 1 | [41] |
| 9p21 | rs10757278 | A | 1.44 (1.08–1.94) | 177 | 182 | 1 | [42] | 1.12 (0.81–1.54) | 1 | [42] |
| RDBP | rs3880457 | C | 0.31 (0.13–0.71) | 136 | 183 | 1 | [21] | NA | ||
| SKIV2L | rs2075702 | C | 0.31 (0.13–0.71) | 136 | 183 | 1 | [21] | NA | ||
| C3 | rs2241394 | C | 3.47 (1.48–8.38) | 100 | 190 | 1 | [29] | NA |