Molecular Vision: Bollinger, Mol Vis 2012; 18:2001-2011. Table 3

Table 3. Proteins decreased in dexamethasone-treated TM cells.

SwissProt accession	Protein	Subcellular source	Sample frequency total=4	Mean protein ratio	SEM	p-value
Stress Response, Cellular Defense and Protein Processing
P17931	Galectin-3	ABD	3	0.80	0.05	0.054
P25786	Proteasome subunit alpha type-1	BD	3	0.79	0.06	0.051
Q96AY3	FK506-binding protein 10**	C	4	0.78	0.04	0.009
Q14697	Neutral alpha-glucosidase AB	C	3	0.77	0.06	0.042
P06703	Protein S100-A6**	BCD	4	0.75	0.03	0.003
P27797	Calreticulin**	ABC	4	0.73	0.09	0.039
P05388	60S acidic ribosomal protein P0	B	3	0.73	0.02	0.003
O95302	FK506-binding protein 9**	C	4	0.71	0.06	0.010
P23284	Peptidyl-prolyl cis-trans isomerase B	C	4	0.69	0.11	0.045
P30040	Endoplasmic reticulum protein ERp29	C	4	0.66	0.05	0.004
P50454	Serpin H1**	C	4	0.52*	0.07	0.003
Cytoskeletal and ECM Interactions
P13797	Plastin-3**	B	4	0.73	0.10	0.048
O15460	Prolyl 4-hydroxylase subunit alpha-2	C	4	0.75	0.09	0.053
Q01995	Transgelin**	B	4	0.78	0.07	0.042
P13674	Prolyl 4-hydroxylase subunit alpha-1	C	4	0.78	0.08	0.055
P48681	Nestin	B	3	0.62*	0.04	0.007
P02452	Collagen alpha-1(I) chain	A	3	0.48*	0.15	0.038
Mitochondrial Metabolism
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	D	3	0.78	0.01	0.004
P22307	Non-specific lipid-transfer protein	BE	4	0.73	0.10	0.049
O75964	ATP synthase subunit gamma	CE	3	0.61*	0.12	0.054

Adjusted mean protein ratios (DEX-treated/Control), standard error of the mean (SEM), p-values and subcellular source are shown for less abundant proteins (from Appendix 5). Less abundant proteins exhibited mean ratios at least 1SD below the mean and p-values ≤0.055 (see Figure 2). All proteins were quantified in ≥3 TM cell samples (median ratio=0.99, mean=1.00, SD=0.21, n=341). Asterisks (*) denote ratios at least 2 SD below the mean. Double asterisks (**) denote CA⁺⁺binding proteins. Protein subcellular source from the Swiss Protein database: A, secreted; B, cytoplasmic; C, membrane; D, nuclear; E, mitochondrial.