Figure 3. Results of genome-wide linkage analysis. A: Family pedigree. The family history revealed eleven affected members in four generations. Squares and circles symbolize males and females, respectively. Clear and blackened symbols denote unaffected and affected individuals. Family members participating in this study are indicated by an asterisk. Those included in the genome-wide scan are also marked with “+.” The arrow points to the index patient. B: Graphical view of multipoint genome-wide LOD scores calculated with ALLEGRO using SNP chip data from family members marked with “+” on Figure 3A. The linkage interval on chromosome 22 encompasses the β-crystallin gene cluster.