Figure 1. Organization of the human CAV-1 and CAV-2 genes and localization of TF binding sites. A: Exon-intron structure of the caveolins genes and localization of SNP rs4236601 marker (modified from [19]). The sizes of exons (white rectangular boxes) and the distance between them (below Y) are shown. Marker rs4236601 is located 2,388 bp upstream from the start codon of CAV-1. B: localization of SNP and putative TF binding sites (ovals) in the upstream region of CAV-1. Other details of TF-binding sites 1–8 are present in Table 2.The sequence of primers used for the modifications of the fragment are presented in Table 1.