Molecular Vision: Jia, Mol Vis 2011; 17:2386-2399. Table 2

Table 2. Enriched gene ontology terms according to biologic process in various groups of genes.

Enriched GO terms in each group	Count^a
G1 group: upregulated in both S-CorNV and CB-CorNV
Cell migration
chemotaxis (see Table 3)	18
leukocyte chemotaxis	9
leukocyte migration	10
locomotory behavior	18
cell migration	12
Host defense responses
immune response (see Table 4)	32
defense response	29
inflammatory response (see Table 5)	21
response to wounding	25
acute inflammatory response	10
acute-phase response	6
response to organic substance	16
response to molecule of bacterial origin	5
antigen processing and presentation of exogenous antigen	6
immunoglobulin mediated immune response	7
B cell mediated immunity	7
lymphocyte mediated immunity	7
positive regulation of response to stimulus	10
regulation of cytokine production (see Table 6)	8
regulation of tumor necrosis factor production	4
response to oxidative stress	6
response to cytokine stimulus	4
positive regulation of acute inflammatory response	3
positive regulation of multicellular organismal process	8
cytokine-mediated signaling pathway	5
defense response to Gram-negative bacterium	3
Tissue development or organization
eye development	10
lens development in camera-type eye	5
multicellular organismal homeostasis	6
extracellular structure organization	8
regulation of biomineral formation	4
regulation of bone mineralization	4
regulation of homeostatic process	6
cellular cation homeostasis	8
collagen fibril organization	4
homeostatic process	17
cellular homeostasis	12
vasculature development	10
epidermis development	7
sensory organ development	10
ectoderm development	7
epithelium development	10
epithelial cell differentiation	7
lens fiber cell differentiation	3
cellular iron ion homeostasis	4
positive regulation of developmental process	9
blood vessel development (refer to Table 7)	10
Metabolism
intermediate filament-based process	4
icosanoid biosynthetic process	4
unsaturated fatty acid biosynthetic process	4
icosanoid metabolic process	4
G2 group: upregulated in S-CorNV, unchanged in CB-CorNV
mitosis	8
nuclear division	8
organelle fission	8
M phase	9
cell cycle phase	9
G3 group: upregulated in S-CorNV, absent in CB-CorNV
not any
G4 group: unchanged in S-CorNV, upregulated in CB-CorNV
chordate embryonic development	9
embryonic development ending in birth or egg hatching	9
endothelial cell morphogenesis	2
G5 group: unchanged in S-CorNV, down-regulated in CB-CorNV
not any
G6 group: down-regulated in S-CorNV, unchanged in CB-CorNV
Lipid metatolism
lipid biosynthetic process	15
steroid metabolic process	12
steroid biosynthetic process	8
cholesterol metabolic process	7
carboxylic acid biosynthetic process	8
organic acid biosynthetic process	8
fatty acid biosynthetic process	6
oxidation reduction	16
Host response
cellular response to extracellular stimulus	5
cellular response to starvation	4
epithelium development	9
Differentiation
epithelial cell differentiation	6
epidermis development	6
keratinocyte differentiation	4
epidermal cell differentiation	4
Wnt receptor signaling pathway	6
ectoderm development	6
regulation of neuron differentiation	5
G7 group: down-regulated in both S-CorNV and CB-CorNV
oxidation reduction (see Table 9)	19
programmed cell death	14
retinol metabolic process	3
G8 group: down-regulated in S-CorNV, absent in CB-CorNV
not any
G9 group: absent in S-CorNV, upregulated in CB-CorNV
response to organic substance	10
response to steroid hormone stimulus	4
immune response	8
oxidation reduction	9
icosanoid metabolic process	3
G10 group: absent in S-CorNV, down-regulated in CB-CorNV
not any

“Enrichment” means that a specific GO terms gives an Expression Analysis Systematic Explore (EASE) score less than 0.01. To simplify the presentation of the enriched terms, the GO terms that obviously duplicate others were not shown. For example, “cellular response to nutrient levels” in Group 6 was not shown due to its duplication to “cellular response to starvation.” Similarly, “Cell death,” “death,” and “apoptosis” in Group 7 were duplicates of “programmed cell death,” thus not shown either. ^aNumbers of probes in the specific group or GO term.