Figure 1. Alignment of TPR2B domains of
STI1. Amino acids 353 to 477 of human STI1 (
H. sapiens, GenBank
NP_006810)
are shown aligned to animal, fungal and plant STI1 sequences
demonstrating evolutionary conservation of the TPR2B domain and residue
K434 (indicated by the arrow). Alignment to the human TPR1 domain was
used for homology modeling (see
Figure 2). Black and gray shading
represent identical and functionally-similar residues, respectively.