Figure 4. The cytotoxic effects of homocysteine-thiolactone (Hcy-T) on specific retinal cells as reflected by alterations of A-D: rhodopsin positive photoreceptors, E-H: calbindin positive horizontal cells, I-L: Chx- 10 positive bipolar cells, M-P: Islet-1 positive bipolar cells, Q-T: Pax-6 positive amacrine cells, and U-X: glial fibrillary acidic protein (GFAP) positive Müller cells at day 15 and day 90 following the intravitreal injections. Abbreviations: GCLrepresents ganglion cell layer; INL represents inner nuclear layer; IPL represents inner plexiform layer; ONL represents outer nuclear layer; OPL represents outer plexiform layer; OS/IS represents outer and inner segments of photoreceptors. Scale bar: 45 μm.