Molecular Vision: Jia, Mol Vis 2011; 17:1493-1507. Table 3

Table 3. Relative expressions of Th17- and Treg- related factors at the mRNA level from retina during monophasic EAU with Lewis rats and standard Pearson correlation analysis.

Genes	Relative expression as fold change						Correlation with	p
	con*	7 d	14 d	21 d	28 d	35 d	IL-17 (r)	(2-tailed)
Initiating factors
IL-6	1.00	1.62	33.01	3.30	2.86	6.92	0.882*	0.020
TGF-β	1.00	1.74	12.47	4.44	4.10	5.53	0.907*	0.013
Expansion factors
IL-23p19	1.00	1.34	1.10	1.15	0.85	1.80	−0.035	0.947
IL-23 (−12) p40	1.00	0.35	278.20	18.27	42.71	296.45	0.954**	0.003
Signature cytokines and receptor
IL-17	1.00	0.10	1573.6	15.05	49.24	80.54	—	—
IL-17F	1.00	0.99	32.22	0.89	1.49	1.47	0.741	0.092
IL-17R	1.00	1.85	19.63	4.07	5.25	3.49	0.874*	0.023
Antigen presentation- associated factors
CD4	1.00	0.73	36.13	NA^#	8.47	4.05	0.959**	0.010
MHC II	1.00	7.31	5202.54	76.47	624.55	993.70	0.906*	0.013
CD8	1.00	0.22	9.58	NA^#	0.83	1.07	0.869	0.056
MHC I	1.00	0.95	8.63	0.66	1.60	3.46	0.790	0.061
Lineage markers
RORγt	1.00	1.10	6.02	0.70	0.92	3.09	0.679	0.138
CCR6	1.00	1.41	62.47	3.05	29.89	22.65	0.911*	0.012
Treg-related
Foxp3	1.00	0.86	10.59	0.84	1.59	4.63	0.839*	0.037
CXCR5	1.00	1.18	8.08	1.54	2.58	3.51	0.948*	0.014
CD25	1.00	1.15	146.02	NA#	18.72	5.14	0.915*	0.029

Notes: The time series data are representative for experiments of three batches of immunization for inducing EAU model in Lewis rats as shown in Figure 1. con*, retina were obtained from CFA control rats at 14 dpi, the relative expression of each gene examined was set as 1.00, respectively; NA^#, the data were not available. Genes showing at least a twofold change were recognized as being significantly altered. Significantly increased expression was labeled in bold and decreased in italic. Standard Pearson analysis was performed between the time series expressions of one of the examined molecules and that of IL-17. *Correlation is significant at the 0.05 level; **Correlation is significant at the 0.01 level (2-tailed).