Table 2 of Shyam, Mol Vis 2010; 16:122-129.

Table 2. Wnt components identified in human trabecular meshwork (TM) cells.

Components in Wnt pathway Genes examined Genes identified
Wnt ligand Wnt1, Wnt2*, Wnt2b, Wnt3, Wnt3a*, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, Wnt8a, Wnt10b*, Wnt11* Wnt2b, Wnt3, Wnt5a, Wnt5b
Transduction protein Dsh1, Dsh2, Dsh3 Dsh1, Dsh2, Dsh3
Receptor Fzd1, Fzd2, Fzd4, Fzd5, Fzd7, Fzd8, LRP5, LRP6 Fzd1, Fzd2, Fzd4, Fzd5, Fzd7, LRP5, LRP6
β-Catenin and Degradation complex CTNNB1, GSK3β, APC CTNNB1, GSK3β, APC
Transcription factor TCF1*, TCF3, TCF4, TCF7 TCF3, TCF4, TCF7
Inhibitor Dkk1, Dkk2, sFRP1, sFRP2, sFRP3 Dkk1, Dkk2, sFRP1, sFRP2, sFRP3

RT–PCR experiments were performed to detect Wnt-related gene transcripts. Primers used for the analyses are given in Table 1. The asterisk indicates that positive PCR products were obtained using MCF-7 or HEK293 cDNAs but not with cDNA from human TM cells.

Shyam, Mol Vis 2010; 16:122-129. http://www.molvis.org/molvis/v16/a15

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