Table 1 of
Amrite, Mol Vis 2008; 14:150-160. Table 1 of
Amrite, Mol Vis 2008; 14:150-160.
Table 1. Model parameters used for simulations of retinal pharmacokinetics after periocular administration of celecoxib in rats as particulate formulations with particle sizes, 20 and 200 nm
| Symbol | Meaning | Value (min−1) |
|---|---|---|
| K10 | Elimination rate constant from periocular site | 0.123 |
| K12 | Absorption rate constant for sclera-choroid-RPE (transfer compartment) | 3.61E-04 |
| K20 | Elimination rate constant from the sclera-choroid-RPE (transfer compartment) | 0.035 |
| K23 | Absorption rate constant for retina from the sclera-choroid-RPE (transfer compartment) | 0.061 |
| K30 | Elimination rate constant form the retina | 0.002 |
| K34 | Rate constant for transfer to the distribution compartment from the retina | 0.045 |
| K43 | Rate constant for transfer to the retina from the distribution compartment | 0.001 |
| Krel | Rate constant for the release of the drug from the formulation | Different values used |
| Kelfor | Rate constant for elimination of the formulation | Value chosen based on the formulation. |