Figure 7. Tight junction genes and known regulators expressed in retinal pigment epithelium

The Protein Lounge database was used to identify members. Close to 50% of the genes identified were developmentally regulated. Although tight junctions are forming during this period, expression of a number of genes was down-regulated. Several genes, such as ZO-3 and claudin 20, increased primarily after E14 when there are few structural changes in the junction. Mean values of 3-4 biological replicates are indicated according to the scale, in arbitrary units, depicted at the bottom. Complete gene titles and mean values with the associated p-statistic are listed in the corresponding Appendix 2.