Table 2 of
Hunter, Mol Vis 2006;
12:588-596.Table 2 of
Hunter, Mol Vis 2006;
12:588-596.
Table 2.
Twenty-one cataract genes mapped onto the canine genome. PCR primers (Table 1) from 21 cataract genes were used for radiation hybrid-mapping using an RH5000 panel. Multimap® two-point linkage analysis was used to identify the chromosome location and two closest markers [17], along with the corresponding LOD score, and θ value (distance). To confirm these locations, PCR amplicons were analyzed against the 7.5X canine draft sequence to obtain sequence-tagged sites (STS) locations, which were compared with the corresponding canine ortholog locations within the draft sequence.
Closest Canine
Gene Chromosome markers LOD θ STS location ortholog location
------ ---------- ----------- ------ ----- ------------------- ------------------
BFSP2 CFA23 REN156G20 22.448 0.086 33427673-33428089 33388029-33450927
REN210D03 17.827 0.169
CX46 CFA25 EST18C6 9.688 0.276 20988791-20989147 20986634-20987933
BAC_372_A23 9.617 0.261
CX50 CFA17 CFOR12C10 20.47 0.056 61506499-61506884 61498923-61505209
PEZ8 19.834 0.058
LIM2 CFA1 KLK2 18.201 0.035 108473188-108473537 108472780-08479290
REN06N11 17.642 0.066
MIP CFA10 FH2537 25.039 0.09 3684287-3684594 3684852-3689232
ATP5B 21.428 0.132
SPARC CFA4 FH4018 14.097 0.048 60879945-60880285 60873070-60887224
BAC_374_E21 12.897 0.093
CRYBB2 CFA26 CRYBB1 25.249 0.043 22335395-22335748 22331283-22338858
REN131L06 24.11 0.064
CRYGA CFA37 AHT133 20.482 0.092 19453604-19453950 19453388-19455353
REN105M20 20.482 0.092
CRYGB CFA37 BAC_381_J22 15.426 0.123 20124535-20124930 19440507-19442393
FH2708 13.738 0.157
CRYGC CFA37 BAC_381_J22 24.954 0 19431676-19432046 19431504-19433284
EST22D1 23.468 0.026
CRYGD CFA37 CRYGB 15.027 0.045 19425779-19426157 19424588-19426264
BAC_374_E1 8.03 0.354
CRYGS CFA34 BAC_374_K23 27.708 0.021 22165843-22166230 22165569-22166681
REN266K05 27.283 0.022
CHX10 CFA8 EST10D4 23.799 0.025 50510969-50511356 50492693-50511026
EST27E3 21.735 0.051
EYA1 CFA29 STS246A16 19.01 0.119 23177126-23177509 23176722-23342854
C29_188 18.473 0.138
FOXE3 CFA15 FH3888 23.211 0.046 16294587-16294926 16295972-16298254
FH3886 22.806 0.047
HSF4 CFA5 AHTH201REN 13.127 0.052 85205320-85205780 85204186-85208678
REN122J03 11.927 0.1
MAF CFA5 FH3450 9.517 0.244 74976764-74977099 74970434-74976948
FH3113 9.427 0.224
PAX6 CFA18 WT1 17.245 0.148 38687699-38688008 38671041-38693640
FH3824 17.15 0.148
PITX3 CFA28 EST3H1 19.137 0.083 17763487-17763792 17761261-17772191
COL17A1 18.606 0.085
SIX5 CFA1 BAC_375_N13 21.594 0 112730879-112731247 112726865-12731063
FH2598 21.594 0
SOX1 CFA22 EST3G2 26.711 0.022 62864830-62865127 62861615-62864949
BAC_376_O1 24.774 0.045
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