Table 4 of
Rozsa, Mol Vis 2006;
12:125-141.Table 4 of
Rozsa, Mol Vis 2006;
12:125-141.
Table 4. Dexamethasone response genes and experimental parameters from other reports
A: Genes with differential expression following dexamethasone treatment identified by other groups are listed with gene symbol, GenBank accession number and the measurement of differential expression used in that study. The average fold calculation is based on dexamethasone-treated HTM compared to dexamethasone-treated optic nerve head astrocytes in Lo et al. [17]. B: Experimental parameters for the three recent microarray studies described in Table 4A.
A:
Lo et al. [17] Isibashi et al. [18] Leung et al. [19] This study
Gene average fold change mean signal ratio expression ratio average fold change
Symbol Genbank (HTM/ONH Astrocytes) (DEX/Control) (log2) (all cell lines)
-------- --------- -------------------- -------------------- ----------------- -------------------
ANGPTL7 NM_021146 28 187.0
SERPINA3 NM_001085 165 48.2
MYOC D88214 50 24 4.32 (qPCR) 16.7
MAOA AA923354 2.4 13.1
ACTG2 NM_001615 30 9.4
APOD NM_001647 22 5.3
MT1X NM_002450 1.9 3.7
TAGLN NM_003186 1.53 3.5
DHCR24 NM_014762 2.1 2.5
KCNB1 L02840 0.5 2.4
BNIP3 NM_004052 2.2 2.3
LTBP2 NM_000428 3.1 2.2
IGFBP2 NM_000597 57 4.9 1.7 2.1
TPM2 NM_003289 2.1 2.1
AKR1C3 AB018580 43 1.5
ATF4 NM_001675 0.55 1.5
MORF4L2 NM_012286 2 1.5
ACTR3 NM_005721 0.5 1.4
CST3 NM_000099 1.95 1.4
SCD AB032261 2.1 1.4
AKR1B10 NM_020299 3.5 1.3
LDHA NM_005566 1.61 1.2
HSPA5 AF216292 0.58 -1.3
IGFBP4 NM_001552 2.5 -1.3
HADHB NM_000183 0.5 -1.4
PER2 NM_022817 2 -1.4
DCN NM_001920 3.5 -1.5
FBLN1 NM_006486 2.8 -1.8
FLRT2 NM_013231 0.4 -2.5
CRABP2 NM_001878 0.3 -3.1
SCG2 NM_003469 0.4 0.64 -3.7
CHI3L1 AJ251847 33 -6.1
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B:
TM
cell Cell Dex Number of
Study lines Age of donors passage exposure genes screened Array type
--------------------- ----- ---------------- ------- -------- ---------------------- ------------------------
Lo et al. [17] 2 not reported 4-6 10 days 9,330 unique clusters Oligonucleotide (U95Av2)
Ishibashi et al. [18] 4 7 to 28 years 4-5 7 days 2,400 cDNA (NEN)
Leung et al. [19] 1 not reported 8 10 days 2,400 cDNA (NEN)
This work 3 12, 16, 17 years 5 21 days 13,507 unique clusters Oligonucleotide (U133A)
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