Table 4 of
Tasheva, Mol Vis 2004;
10:403-416.Table 4 of
Tasheva, Mol Vis 2004;
10:403-416.
Table 4. Genes down-regulated more than two fold in the lens of mimecan-null mice
Genes for which changed expression has been verified by PCR are indicated in red.
GenBank accession Fold number Gene name change p value Functional category --------- --------------------------------- ------------ --------- --------------------------------- NM_010496 inhibitor of DNA binding 2 2.0252808 0.00704 transcription activators and repressors NM_013647 ribosomal protein S16 2.21952412 0.00944 ribosomal proteins L05670 clusterin 2.25893123 0.0131 other stress response proteins NM_009180 sialyltransferase 7 2.28313623 0.0265 terminal glycosylations, protein maturation NM_010299 GM2 ganglioside activator protein 2.29604607 0.0214 protein cofactor NM_013602 metallothionein 1 2.42609714 0.00709 intracellular metal transport NM_009795 calpain, small subunit 1 2.50084674 0.0054 cysteine proteases NM_009225 small nuclear ribonucleoprotein B 2.52684834 0.00724 mRNA splicing NM_007774 crystallin, gamma A 2.53653929 0.255 functionally unclassified NM_010240 ferritin light chain 1 2.75262797 0.0468 other metabolism enzymes X84014 laminin, alpha 3 2.77294799 0.0382 matrix adhesion receptors NM_010833 moesin 2.8778955 0.0175 functionally unclassified X83536 matrix metalloproteinase 14 2.95622774 0.0288 metalloproteinases (membrane-inserted) X62622 tissue inhibitor of 2.96603146 0.0433 inhibitors of proteases metalloproteinase 2 NM_020031 prefoldin 5 2.97737665 0.02 chaperonin cofactor NM_008184 glutathione S-transferase, mu 6 3.08599668 0.014 metabolism of cofactors, vitamins NM_008160 glutathione peroxidase 1 3.22557188 0.0448 metabolism of cofactors, vitamins M16465 S100 calcium binding protein A10 3.42359415 0.0224 other intracellular effectors (calpactin) NM_009113 S100 calcium binding protein A13 3.66024878 0.00267 other intracellular effectors Z30970 tissue inhibitor of 3.72407092 0.0362 inhibitors of proteases metalloproteinase 3 NM_013529 glutamine fructose-6-phosphate 3.77507728 0.000847 not classified transaminase 2 NM_019803 ubiquitin-conjugating enzyme E2G2 3.90705613 0.0155 ubiquitin pathway NM_011521 syndecan 4 3.9878813 0.00404 cell adhesion receptors/proteins L47650 signal transducer and activator 4.02337548 0.0283 transcription activators and of transcription 6 repressors U14332 interleukin 15 4.02388515 0.0345 interleukins and interferons NM_009813 calsequestrin 1 4.4443481 0.00442 calcium-binding proteins X16053 thymosin, beta 4, X chromosome 4.5522899 0.00137 growth factors, cytokines, and chemokines NM_010730 annexin A1 4.87212946 0.00198 calcium-binding proteins L07918 Rho, GDP dissociation inhibitor 4.92527206 0.0248 intracellular (GDI) beta transducers/effectors/modulators NM_008788 procollagen C-proteinase enhancer 5.17209839 0.000467 extracellular matrix glycoprotein protein NM_009105 Ras suppressor protein 15.17691889 0.00164 not classified NM_007598 adenylyl cyclase-associated CAP 5.20181404 0.00266 other intracellular effectors protein homolog NM_013471 annexin A4 5.75746911 0.0114 other intracellular effectors NM_010231 flavin containing monooxygenase 1 5.81538897 0.00462 xenobiotic metabolism NM_008529 lymphocyte antigen 6 complex, 5.88922963 0.000738 cell surface antigens locus E U77039 four and a half LIM domains 1 5.88945864 0.0037 cytoskeleton/motility proteins NM_010129 epithelial membrane protein 3 5.97518779 0.00485 cell-cell adhesion receptors NM_008476 keratin complex 2, basic, gene 6a 6.58282353 0.00158 intermediate filament proteins NM_016969 myeloid-associated 6.64636547 0.0354 markers of differentiation differentiation marker NM_009735 beta-2 microglobulin 7.26879193 0.00366 major histocompatibility complex NM_011526 transgelin 7.53204256 0.00205 cytoskeleton/motility proteins X59060 myogenic factor 6 8.34758235 0.00193 basic transcription factors NM_007751 cytochrome c oxidase, subunit 8.66157948 0.0336 metabolism VIIIb X89222 prostaglandin D2 synthase (brain) 9.08436981 0.00105 metabolism of cofactors, vitamins, and related NM_010442 heme oxygenase (decycling) 1 9.21634953 0.00242 metabolism of cofactors, vitamins, and related AF039601 transforming growth factor, beta 9.52799861 0.0444 growth factor and chemokine receptor III receptors NM_007921 E74-like factor 3 9.90125073 0.00299 basic transcription factors NM_011157 proteoglycan, secretory granule 9.91067047 0.00519 other extracellular communication proteins X03492 keratin complex 1, acidic, gene 10.2246991 0.0195 intermediate filament proteins 13 NM_015744 ectonucleotide 10.5952984 0.000198 not classified pyrophosphatase/phosphodiesterase 2 NM_009405 troponin I, skeletal, fast 2 11.2401959 0.00135 motor proteins NM_010501 interferon-induced protein 3 11.3860933 0.0457 functionally unclassified NM_007689 chondroadherin 11.3882785 0.0105 extracellular matrix proteins M84324 matrix metalloproteinase 2 11.8380719 0.000778 metalloproteinases NM_007585 annexin A2 11.9290914 0.000297 calcium-binding proteins NM_008218 hemoglobin alpha, adult chain 1 12.5534642 0.0123 other metabolism enzymes NM_008557 FXYD domain-containing ion 12.6277299 0.000422 functionally unclassified transport regulator 3 U18869 disabled homolog 2 (Drosophila) 14.3294003 0.000253 other intracellular effectors NM_010357 glutathione S-transferase, alpha 14.9525947 0.0118 xenobiotic metabolism 4 NM_007933 enolase 3, beta muscle 15.1527472 0.0000605 not classified L20276 biglycan 15.3346648 0.00674 extracellular matrix proteins NM_013645 parvalbumin 15.4807731 0.00115 calcium-binding proteins X70296 serine (or cysteine) proteinase 15.782717 0.00188 inhibitors of proteases inhibitor, member 2 NM_010362 glutathione S-transferase omega 1 18.2983278 0.00159 metabolism of cofactors, vitamins, and related D89076 transthyretin 22.187204 0.00136 extracellular transport/carrier proteins NM_015734 procollagen, type V, alpha 1 29.0842381 0.00953 extracellular matrix proteins NM_007606 carbonic anhydrase 3 31.4559099 0.000418 other metabolism enzymes NM_011620 troponin T3, skeletal, fast 31.7252921 0.00918 motor proteins NM_009416 tropomyosin 1, alpha 41.0419782 0.000317 motor proteins NM_009393 troponin C, cardiac/slow skeletal 43.7999523 0.000154 other cytoskeleton/motility proteins NM_010661 keratin complex 1, acidic, gene 45.3038064 0.000924 intermediate filament proteins 12 NM_007436 aldehyde dehydrogenase family 3, 47.9414644 0.000252 simple lipid metabolism subfamily A1 NM_007409 alcohol dehydrogenase 1 (class I) 100.983218 0.0000752 energy metabolism NM_007817 cytochrome P450, family 2, 101.998516 0.00305 metabolism polypeptide 2 NM_007504 ATPase, Ca++ transporting, fast 227.439828 0.00117 energy metabolism twitch 1 NM_007470 apolipoprotein D 745.16573 0.0138 extracellular transport/carrier proteins |