Table 3 of
Tasheva, Mol Vis 2004;
10:403-416.Table 3 of
Tasheva, Mol Vis 2004;
10:403-416.
Table 3. Genes up-regulated more than two fold in the lens of mimecan-null mice
Genes for which changed expression has been verified by PCR are indicated in red.
GenBank accession Fold number Gene name change p value Functional category --------- ------------------------------ ----------- --------- ------------------------------ NM_019920 MAPKK1 interacting protein 1 2.07725624 0.0316 kinase activators and inhibitors AF020737 fibroblast growth factor 13 2.25560511 0.0183 intracellular effectors NM_019511 receptor (calcitonin) activity 2.27681851 0.0157 protein transporter activity modifying protein 3 NM_009682 adaptor-related protein 2.45750185 0.0207 adaptors (receptor-associated) complex 3 proteins NM_007516 heterogeneous nuclear 2.45881799 0.00756 AU-rich element ribonucleoprotein D RNA-binding protein NM_009729 ATPase, H+ transporting, 2.48106312 0.00494 ATPase transporters lysosomal,subunit C NM_019498 olfactomedin 1 2.50527134 0.0103 secreted glycoproteins M20658 interleukin 1 receptor, type I 2.62788637 0.0488 interleukin and interferon receptors J00423 hypoxanthine guanine 2.63535944 0.0244 nucleotide metabolism phosphoribosyl transferase NM_007675 CEA-related cell adhesion 2.68535113 0.0023 cell adhesion molecule 10 receptors/proteins NM_011514 suppressor of variegation 3-9 2.68872221 0.0115 chromatin proteins homolog NM_007589 calmodulin 2 2.74742803 0.0352 calcium-binding proteins NM_017477 coatomer protein complex, 2.75948715 0.00463 early secretory transport subunit gamma 1 NM_019997 RIKEN cDNA 3830408P04 gene 2.75987162 0.005 not classified NM_013677 surfeit gene 1 2.82043434 0.00601 housekeeping genes NM_016686 vascular endothelial zinc 2.92688193 0.0167 transcription factor, finger 1 regulation of angiogenesis NM_010324 glutamate oxaloacetate 2.94837086 0.033 amino acid metabolism transaminase 1, soluble NM_009801 carbonic anhydrase 2 3.03266702 0.0178 other metabolism enzymes NM_008801 phosphodiesterase 6D, 3.04325549 0.00709 adenylate/guanylate cyclases cGMP-specific, rod, delta and diesterases NM_010761 cyclin D-type binding-protein1 3.04531832 0.0396 transcription activators and repressors NM_013746 pleckstrin homology domain 3.23477235 0.0371 actin assembly and containing, family B,1 cell polarization D00472 cofilin 1, non-muscle 3.31937972 0.0302 cytoskeleton/motility proteins L09104 glucose phosphate isomerase 1 3.33192228 0.00178 growth factors, cytokines, and chemokines NM_009905 CDC-like kinase 3.37068281 0.000235 RNA processing, turnover, and transport NM_013680 synapsin I 3.47140615 0.0187 synaptic vesicles localization; microtubules assembly X14943 contactin 1 4.11246046 0.0291 cell adhesion receptors/proteins X53476 high mobility group 4.54086807 0.0209 chromatin proteins nucleosomal binding domain 1 X63003 vitronectin 4.55603215 0.00477 cytoskeleton/motility proteins NM_010045 Duffy blood group 4.63375237 0.00341 cell surface antigens NM_009133 stathmin-like 3 5.13387129 0.0105 not classified M28730 tubulin, beta 4 5.17572104 0.0403 cytoskeleton/motility proteins NM_007765 collapsin response mediator 5.22380123 0.00124 other intracellular effectors protein 1 NM_007885 solute carrier family 26, 5.77272511 0.0386 facilitated diffusion proteins member 2 NM_013865 N-myc downstream regulated 3 6.05719708 0.00192 not classified NM_012038 visinin-like 1 6.11323414 0.0271 not classified NM_008594 milk fat globule-EGF factor 8 6.41856141 0.0147 cell adhesion protein receptors/proteins NM_011430 synuclein, gamma 6.48808425 0.0000861 not classified X15830 secretory granule 6.82683033 0.000716 neuropeptides neuroendocrine protein 1 NM_010655 karyopherin (importin) alpha 2 6.88435378 0.00401 not classified NM_019634 transmembrane 4 superfamily 7.06673969 0.0329 not classified member 2 NM_013509 enolase 2, gamma neuronal 7.18792002 0.00135 simple carbohydrate metabolism M26283 homeo box B5 7.71166469 0.0136 transcription activators and repressors NM_009295 syntaxin binding protein 1 8.1196002 0.00483 not classified NM_008140 guanine nucleotide binding 8.58883045 0.00157 not classified protein, alpha transducing 1 NM_011302 retinoschisis 1 homolog 9.25022252 0.00127 not classified (human) NM_011810 Fas apoptotic inhibitory 10.1427677 0.0172 not classified molecule NM_008141 guanine nucleotide binding 10.3257464 0.00309 not classified protein, alpha transducing 2 NM_008806 phosphodiesterase 6B, cGMP, 10.9403718 0.00266 adenylate/guanylate cyclases rod receptor, beta and diesterases D85845 neurogenic differentiation 4 11.1670862 0.0488 transcription activators and repressors NM_009897 creatine kinase, mitochondrial 12.715274 0.00316 energy metabolism 1, ubiquitous NM_008142 guanine nucleotide binding 13.0898411 0.000686 not classified protein, beta 1 NM_019754 transgelin 3 13.3362329 0.000392 not classified NM_008790 Purkinje cell protein 2 (L7) 13.345321 0.00287 not classified L14935 neural retina leucine zipper 13.5761444 0.00241 transcription gene NM_010316 G protein, gamma 3 subunit 15.209885 0.00398 G-proteins NM_008076 GABA-A receptor, subunit rho 2 15.6166725 0.0234 ligand-gated ion channel NM_009073 rod outer segment membrane 15.9652352 0.0033 matrix adhesion receptors protein 1 NM_007538 opsin 1 (cone pigments), 16.4802471 0.000631 other receptors (by ligands), short-wave-sensitive G-protein-coupled NM_009065 Ras-like without CAAX 2 17.0368293 0.00541 not classified M24086 retinal S-antigen 17.7124286 0.0466 adaptors and receptor-associated proteins NM_008106 opsin 1 (cone pigments) 22.6283609 0.00948 other receptors (by ligands), medium-wave-sensitive G protein-coupled U77615 cone-rod homeobox containing 23.0625976 0.0302 basic transcription factors gene NM_012065 phosphodiesterase 6G, 23.0861147 0.000086 adenylate/guanylate cyclases cGMP-specific, gamma and diesterases X66196 recoverin 23.403064 0.00154 calcium-binding proteins X68837 secretogranin II 33.095184 0.0474 neuropeptides |