Figure 1. Schematic of APC alternative splice-forms

This figure is a partial schematic representation of the APC alternative splice-forms identified in the retina/RPE RNA. Exon 1 encodes a translational initiation site (arrow). The 5' exons 0.3 and BS also contain initiation codons that are in-frame with exon 2 (arrows). The upstream stop codon (*) in exon 1 will prevent the in-frame translations from the 5' exons 0.3 and BS unless exon 1 is excluded by splicing.