Figure 6 of
Zhang, Mol Vis 2003;
Figure 6. MEKK1 is required for the formation of tight junctions in the corneal epithelium
Embryonic eye sections of wild type and Mekk1 homozygous mutant mice at E15.5 and E16.5 were studied by immunostaining for adherens junctions with anti-E-cadherin (A) and anti-β-catenin (B), desmosomes with anti-desmoplakin (C) and anti-desmoglein (D), and tight junctions with anti-ZO-1 (E) and anti-occludin (F). MEKK1 ablation caused a disturbance in corneal epithelium of tight junctions but not adherens junctions and desmosomes because the expression of ZO-1 and occludin is detected in the corneal epithelium of wild type fetuses, but not in the mutants. The expression of E-cadherin, β-catenin, desmoplakin, and desmoglein is unaltered by MEKK1 ablation.