Figure 2. Haplotypes of ARA families

A: Haplotype of family ARA7 exhibiting the Q123X mutation. Darkened bars indicate the affected haplotype. The order of the markers from telomere to centromere and their inter-marker distances are: D6S1574-4.7 cM-D6S309-4.8 cM-D6S470. Note that the affected haplotype 1-1-1 is segregating in this family, and the grandmother (ARA7G) is also carrying the same haplotype. "Mt" and "Wt" represent the mutant and wild type chromosomes, respectively. B: Haplotype of family ARA3 and ARA8 exhibiting the M161K mutation. Darkened bars indicate the affected haplotype. The order of the markers from telomere to centromere and their inter-marker distances are: D6S1574-4.7 cM-D6S309-4.8 cM-D6S470. Note the affected haplotypes 1-3-1 and 3-2-2 segregating in ARA3 and ARA8 family, respectively. "Mt" and "Wt" represent the mutant and wild type chromosomes, respectively.