Table 4 of
Ruotolo, Mol Vis 2003;
9:538-548.Table 4 of
Ruotolo, Mol Vis 2003;
9:538-548.
Table 4. Genes differentially expressed in cataractous lens epithelia compared to transparentepithelia
Cataract downregulated and upregulated genes (corresponding to flag 0 or flag 2 spots) with a greater than or equal to 5- or 3-fold variation, respectively, are listed in a decreasing order of fold-variation. The complete list of modulated genes is given in Appendix 1.
Downregulated genes Accession Flag Flag number Title Gene Chromosome N1/N2 IN C1/C2 IC IN/IC --------- ------------------------ --------- ---------- ----- ---- ----- ---- ----- AA291490 glucosidase I GCS1 2 0/0 3.29 2/2 0.20 16.29 H53703 growth factor GRB7 17 0/0 2.43 2/2 0.20 12.06 receptor-bound protein 7 AA701860 follistatin FST 5 0/0 2.07 2/2 0.20 10.24 AA027042 Pol (RNA) II (DNA POLR2E 19 0/0 2.06 2/2 0.20 10.20 directed) polypeptide E AA454218 TBP associated TAF1C 16 0/0 1.92 2/2 0.20 9.51 factor.RNA polI.C AA443547 v-rel avian RELA 11 0/0 1.85 2/2 0.20 9.16 reticuloendotheliosis viral oncogene AA147640 phosphorylase, glycogen PYGL 14 0/0 1.72 2/2 0.20 8.54 T72202 signal transducer and STAT6 12 0/0 1.57 2/2 0.20 7.78 activator of transcription 6 N64051 Werner syndrome WRN 8 0/0 1.53 2/2 0.20 7.59 AA164440 pericentriolar material1 PCM1 8 0/0 1.51 2/2 0.20 7.50 N81029 collagen, type XVIII, COL18A1 21 0/0 1.49 2/2 0.20 7.39 alpha 1 AA430512 serine (or cysteine) SERPINB9 6 0/0 1.49 2/2 0.20 7.37 proteinase inhibitor AA463924 coagulation factor F8A X 0/0 2.33 0/2 0.32 7.33 VIII-associated AA884403 cardiotrophin 1 CTF1 16 0/0 1.44 2/2 0.20 7.15 AA099169 phosphofructokinase PFKM 12 0/0 1.42 2/2 0.20 7.06 AA443039 heat shock 70 kD HSPA1B 6 0/0 1.42 2/2 0.20 7.02 protein 1B AA454854 amylase, alpha 2A AMY2A 1 0/0 1.38 2/2 0.20 6.85 H79353 Fc fragment of IgE FCER1G 1 0/0 1.35 2/2 0.20 6.66 AA644128 nuclear autoantigenic NASP 1 0/0 1.31 2/2 0.20 6.51 protein (histone-binding) AA134814 TRAF family TANK 2 0/0 1.29 2/2 0.20 6.41 member-associated NFKB activator T55558 colony stimulating CSF1 1 0/0 1.28 2/2 0.20 6.34 factor 1 AA488622 signal transducing STAM 10 0/0 1.28 2/2 0.20 6.32 adaptor moleculeSH3 domain R44005 glutamate decarboxylase2 GAD2 10 0/0 1.26 2/2 0.20 6.26 AA877347 putative b.b- B-DIOX-II 11 0/0 1.25 2/2 0.20 6.18 carotene-9', 10'-dioxygenase AA844124 Homo sapiens, clone 14 0/0 1.24 2/2 0.20 6.13 IMAGE:4070070 AA496792 ESTs 9 0/0 1.22 2/2 0.20 6.03 AA127100 ribophorin I RPN1 3 0/0 1.21 2/2 0.20 6.00 AA431795 hypothetical protein EDAG-1 9 0/0 1.21 2/2 0.20 6.00 EDAG-1 AA449753 capping protein (actin CAPZA1 1 0/0 1.18 2/2 0.20 5.83 filament) muscle Z-line, alpha 1 AA401972 RAB2, member RAS RAB2L 6 0/0 1.71 0/2 0.31 5.53 oncogene family-like AA427906 beclin 1 BECN1 17 0/0 1.11 2/2 0.20 5.49 AA421783 zinc finger protein 263 ZNF263 16 0/0 1.11 2/2 0.20 5.49 AA478724 insulin-like growth IGFBP6 12 0/0 1.11 2/2 0.20 5.48 factor binding protein 6 AA458630 renin REN 1 0/0 1.10 2/2 0.20 5.44 AA458982 sodium channel, SCNN1A 12 0/0 1.09 2/2 0.20 5.39 nonvoltage-gated 1 alpha N51278 chemokine (C-X3-C) CX3CR1 3 0/0 1.09 2/2 0.20 5.38 receptor 1 R60150 histidyl-tRNA synthetase HARS 5 0/0 1.08 2/2 0.20 5.33 AA490855 0/0 1.05 2/2 0.20 5.21 AA488247 amyloid β(A4) APBB1 11 0/0 1.43 0/2 0.28 5.21 precursor protein-binding, family N23898 G protein-coupled GPRK2L 4 0/0 1.04 2/2 0.20 5.17 receptor kinase 2 (Drosophila)-like N73499 GTP-binding protein ragB RAGB X 0/0 1.02 2/2 0.20 5.05 |
Upregulated genes Accession Flag Flag number Title Gene Chromosome N1/N2 IN C1/C2 IC IN/IC --------- ------------------------ --------- ---------- ----- ---- ----- ---- ----- H72028 gelsolin (amyloidosis, GSN 9 2/2 0.21 0/0 1.32 6.38 Finnish type) AA293653 phosphoprotein enriched PEA15 1 2/2 0.21 0/0 1.22 5.92 in astrocytes 15 AA504656 latent transforming LTBP1 2 2/2 0.21 0/0 1.12 5.42 growth factor βbinding protein 1 AA070226 selenoprotein P, plasma,1 SEPP1 5 2/2 0.21 0/0 0.99 4.72 AA487460 dihydropyrimidinase-like2 DPYSL2 8 2/2 0.21 0/0 0.71 3.40 |