Figure 4. Comparative distribution of lens-expressed and cataract-downregulated genes within different functional classes

The histogram shown, represents a subset of Gene Ontology classes (from the "Biological process", "Cellular component" and "Molecular function" categories [14]), in which the number of downregulated genes is significantly higher (the five top sets of bars) or lower (the four bottom sets of bars) than expected (Fisher's Exact Test, P<0.05). The x-axis represents the percentage of genes within each functional class. Lens-expressed gene classes are indicated by blue bars; cataract-downregulated gene classes are indicated by green bars.