Table 2 of Young, Mol Vis 2003; 9:508-514.

Table 2. Human scleral ESTs matched to known genes in GenBank and UniGene databases

The table lists known human genes identified among human scleral ESTs grouped according to (putative) function or cellular localization.

    Putative identified protein and its gene symbol (if known)

Cell cycle/proliferation/survival

    Endothelial differentiation-related factor 1 (EDF1)
    Lectin, galactoside-binding, soluble, 1 (galectin 1)

Cell surface markers/cell adhesion

    Cerebral cell adhesion molecule (LOC51148)

Cellular metabolism

    Milk fat globule-EGF factor 8 protein (MFGE8)
    Nonmetastatic cells 2, protein (NM23B)
    Apolipoprotein D gene, exon 4 (APOD)
    Vesicle-associated membrane protein 2 (synaptobrevin 2; VAMP2)
    EBNA-2 co-activator (100 kD; p100)
    Thy-1 glycoprotein and Thy-1 co-transcribed protein
    Apolipoprotein L-II minor splice variant beta
    Golgi membrane sialoglycoprotein MG160 (LOC112781)
    esterase D/formylglutathione hydrolase (ESD)
    NADH dehydrogenase 1, clone IMAGE: 4120469
    Prostaglandin D2 synthase (21 kD, brain)
    Phospholipase A2, group IIA9 platelets, synovial fliud (PLA2G2A)
    Glyceraldehyde-3-phosphate dehydrogenase (GAPD)
    Nicotinamide N-methyltransferase (NNMT)
    Lysyl oxidase-like 1 (LOXL1)
    A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
    Ubiquitin specific protease 11 (USP11)
    NADH dehydrogenase 4, clone IMAGE: 4041417
    Protein tyrosine phosphatase, receptor type, U (PTPRU)
    N-acetyltransferase, homolog of S. cerevisiae ARD1 (ARD1)
    ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21 kD (ATP6F)
    Glutathione S-transferase subunit 13 homolog (LOC51064)
    Malate dehydrogenase 2, NAD (mitochondrial; MDH2)
    Glutathione peroxidase 3 (plasma; GPX3)
    ATPase, Na+/K+ transporting, beta 3 polypeptide (ATP1B3)
    Phospholipase A2, group IIA (platelets, synovial fluid; PLA2G2A)
    Phosphodiesterase 6G, cGMP-specific, rod, gamma (PDE6G)
    CMP-NeuAC: (beta)-N-acetylgalactosaminide(alpha)2,6-sialyltransferase member VI (VI)
    Cytochrome c oxidase III, mRNA (MTCO3)
    Cytochrome c oxidase II, mRNA (MTCO2)
    Cytochrome c oxidase subunit VIb, Mrna (COX6B)
    Cytochrome c oxidase subunit Vb
    Humanin (HN1)
    Neutrophil gelatinase associated lipocalin (NGAL)
    Ferritin, light polypeptide (FTL)
    Ferritin, heavy polypeptide 1 (FTH1)
    BCL2-associated athanogene (BAG1)
    Cystatin C (amyloid angiopathy and cerebral hemorrhage; CST3)
    Ubiquitin-like protein smt3b (SENTRIN 2; H. sapiens; LOC96576)

Channel proteins

    G protein pathway supressor 2 (GPS 2), transcript variant 3
    S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light)
    Polypeptide (p11; S100A10)
    S100 calcium-binding protein A13


    myosin regulatory light chain 2, smooth muscle isoform (MYL2)
    myosin, light polypeptide 6, alkali, smooth muscle and non-muscle (MYL6)
    actinin, alpha 1 (ACTN1)
    actin, beta (ACTB)
    keratin 13 (KRT13)

Extracellular matrix

    laminin, beta 1 (LAMB1)
    collagen, type X, alpha 1 (COL10A1)
    crystallin, alpha A (CRYAA)
    integrin, beta 5 (ITB5)
    Vimentin (VIM)
    Tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase
        inhibitor; TIMP1)
    Human biglycan BGN
    Syndecan-1 gene (exon 2-5; SDC1)
    Transgelin (TAGLN)
    Fibulin 1 (FBLN1)
    Actinin, alpha 1 (ACTN1)
    Fibulin-1 isoform D precursor
    Decorin (DCN)
    Actin, beta (ACTB)
    Fibromodulin (FMOD)
    Matrix Gla protein (MGLAP)
    Proline arginine-rich end leucine-rich repeat protein (PRELP)


    Pyruvate kinase, muscle, mRNA (PK3)
    Pyruvate kinase, muscle (PKM2)
    RET gene
    PPARA gene

Neuronal specific

    GABA(A) receptor-associated protein (GABARAP)

Protein processing/trafficking

    Phospholipid transfer protein (PLTP)
    Heat shock protein 105 kD (HSP 105 B)
    Ribonuclease, Rnase A family, 1 (pancreatic; RNASE1)
    Protein phosphatase 1, regulatory subunit 10 (PPP1R10)
    Homocysteine-inducible, endoplasmic reticulum stress-inducible,
    ubiquitin-like domain member 1 (HERPUD1)
    Dynein, cytoplasmic, light intermediate polypeptide 2 (DNCLI2)


    Protease, serine, 11 (IGF binding; PRSS11)
    Proteasome (prosome, macropain) subunit, beta type, 7 (PSMB7)
    Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (PSMD4)
    Cathepsin D (lysosomal aspartyl protease; CTSD)

RNA processing

    Small nuclear ribonucleoprotein D2 polypeptide (916.5 kD; SNRPD2)
    U6 snRNA-associated Sm-like protein (LSM2)
    Phenylalanyl-tRNA synthetase beta-subunit
    Clone 11 pur alpha-associated ribosomal RNA gene

Serum/blood cell proteins

    Allograft inflammatory factor 1 (AIF1)
    Antigen identified by monoclonal antibodies 12E7, F21 and O13
    Meningioma expressed antigen 5 (hyaluronidase; MGEA5)
    Retinol-binding protein 4, plasma (RBP4)
    Ig Kappa (IGKC)
    IgM heavy chain (IGHM)
    (fetal) Rearranged IgM chain VDJ-region
    Immunoglobulin gamma heavy chain (T6J/g)
    (hybridoma H210) Anti-hepatitis A IgG variable region
    Immunoglobulin heavy constant gamma 3 (G3m marker; IGH3)
    Clone 23u-1 immunoglobulin heavy chain variable region (IGH)
    Partial mRNA for immunoglobulin heavy chain constant region gamma 4 (IGHG4 gene)
    Myeloma immunoglobulin heavy chain Fd region V-D-J-CH1
    Clone CAZ immunoglobulin light chain variable region gene
    Ig lambda light chain variable region gene (17-25OIVG7)
    Rearranged; Ig-Light-Lambda; V lambda
    Major histocompatibility complex, class I HLA-Bw62 3' end
    Major histocompatibility complex, class II, DP beta 1 (HLA-DPB1)
    HLA-A gene, HLA-A24 allele (HLA-A)
    T-cell gamma receptor locus

Signaling molecules/growth factors/receptors

    Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
    Interleukin enhancer binding factor 3, 90 kD (ILF3)
    Insulin-like growth factor binding protein 6 (IGFBP6)
    Signal recognition particle 72 kD (SRP72)
    Double stranded RNA activated protein kinase (PKR) gene, 3' flanking region
    Human lymph homing receptor (Lnhr)
    Stratifin (SFN)
    Regulator of G-protein signaling-16 (RGS16) gene

Transcription/nuclear-specific proteins

    transcription factor (SMIF gene)
    ZNF gene family member (ZNF)
    zinc finger protein 106 (ZFP106)
    zinc finger protein 16 (KOX 9)
    nucleolar phosphoprotein p130
    high-mobility group (nonhistone chromosomal) protein isoforms I and Y (HMGIY)
    KRAB-associated protein 1 (TIF1B)
    similar to leucine-zipper protein FKSG13
    putative nucleolar RNA helicase (NOH61)
    NADH-ubiquinone oxidoreductase AGGG subunit precursor
    (nuclear gene encoding mitochondrial protein)
    LMO1 gene
    Testis enhanced gene transcript (TEGT)

Translation/protein synthesis

    Eukaryotic translation intiation factor 3, subunit 8 (110 kD; EIF3S8)
    Eukaryotic translation elongation factor 1 gamma (EEF1G)
    Eukaryotic translation elongation factor 1 alpha 1, (EEF?)
    Interferon regulatory factor 3 (IRF3)
    Very long-chain acyl-CoA synthetase homolog 2 (VLCS-H2)
    Ribosomal protein  L4
    Ribosomal protein  L8
    Ribosomal protein  L10
    Ribosomal protein  L11
    Ribosomal protein  L12
    Ribosomal protein  L13
    Ribosomal protein  L13a
    Ribosomal protein  L18
    Ribosomal protein  L19
    Ribosomal protein  L21
    Ribosomal protein  L26
    Ribosomal protein  L29
    Ribosomal protein  L41
    Ribosomal protein, large P2
    Ribosomal protein  S2
    Ribosomal protein  S6
    Ribosomal protein  S8
    Ribosomal protein  S9
    Ribosomal protein  S10
    Ribosomal protein  S18
    Ribosomal protein  S24
    Ribosomal protein  S25


    ADP-ribosylation factor 3 (ARF3)
    Small EDRK-rich factor 2 (SERF2)
    TRIAD3 protein
    Sex-regulated protein janus-a
    CD151 antigen
    Interferon induced transmembrane protein 3 (1-8U)
    Interferon induced transmembrane protein 1 (9-27)
    Clusterin (complement lysis inhibitor, SP-40, sulfated glycoprotein 2,
        testosterone-repressed prostate message 2, polipoprotein J; CLU)
    Membrane protein of cholinergic synaptic vesicles (VATI)
    Adaptor protein complex AP-2, mu1
    30 kDa protein (LOC55831)
    DnaJ (Hsp40) homolog, subfamily B, member 12 (DNAJB12)
    Signal recognition particle 14 kD (homologous Alu RNA-binding protein; SRP14)
    CpG island DNA genomic Mse fragment 1
    Sequestosome 1 (SQSTM1)
    Keratin 13 (KRT13)
    ETV6 gene
    Thioredoxin, mitochondrial
    Complement component 3 (C3)
    Alpha 1,2-mannosidase
    Displacement loop (D-loop) region of human KB cell mitochondrion with adjoining part
        of tRNA genes
    Haptoglobin (HP)
    CD14 antigen

Unknown function

    Homoer-3B protein
    DKFZP586A0522 protein (DKFZP586A0522)
    HNOEL-iso protein (HNOEL-iso)
    SNC73 protein (SNC73)
    Transmembrane adapter protein KAP10 (KAP10)
    Sestrin 2 (SES2)
    Sedum sediforme maturase K (matK)
    Prothymosin, alpha (gene sequence 28)
    Osa, clone IMAGE: 3866722
    Dedicator of cyto-kinesis 3 (DOCK3)
    Transducer of ERBB2, 1 (TOB1)
    RIKEN cDNA 2810468K17 gene
    gC1qR/p32 gene
    Unknown (protein for MGC: 14173)

Hypothetical genes

    Hypothetical protein FLJ11749  H
    Hypothetical protein FLJ23277
    Hypothetical glycine-rich protein [Mesorhizobium loti]
    Hypothetical protein FLJ20608
    Hypothetical protein DKFZp761F241
    Hypothetical protein, expressed in osteoblast (GS3686)
    Hypothetical protein RG083M05.2
    Hypothetical protein FLJ22474
    Hypothetical protein FLJ20327
    Hypothetical protein FLJ10315
    Hypothetical protein MGC10974
    cDNA FLJ14538 fis
    cDNA FLJ10145 fis
    Hypothetical protein FLJ14154
    Hypothetical protein FLJ14038
    cDNA FLJ10158 fis
    Hypothetical gene ZD52F10
    Hypothetical protein BC002942
    cDNA: FLJ22128 fis
    cDNA: FLJ22803 fis
    Hypothetical protein MGC2491
    Hypothetical protein FLJ13171
    Hypothetical protein (LOC51059)

Non-human Genes with Significant Homology to Human Sclera ESTs

    Mus musculus guanylate nucleotide binding protein 3 (Gbp3)
    Ortholog of mouse ZFP289 (ZFP289)
    Arabidopsis thaliana chromosome 5
    Sprouty (Drosophila) homolog 4 (SPRY4)

Young, Mol Vis 2003; 9:508-514 <>
©2003 Molecular Vision <>
ISSN 1090-0535