Table 2 of
Young, Mol Vis 2003;
9:508-514.
Table 2. Human scleral ESTs matched to known genes in GenBank and UniGene databases
The table lists known human genes identified among human scleral ESTs grouped according to (putative) function or cellular localization.
Clone Putative identified protein and its gene symbol (if known) ----------------------------------------------------------------------------------------- Cell cycle/proliferation/survival Endothelial differentiation-related factor 1 (EDF1) Lectin, galactoside-binding, soluble, 1 (galectin 1) Cell surface markers/cell adhesion Cerebral cell adhesion molecule (LOC51148) Cellular metabolism Milk fat globule-EGF factor 8 protein (MFGE8) Nonmetastatic cells 2, protein (NM23B) Apolipoprotein D gene, exon 4 (APOD) Vesicle-associated membrane protein 2 (synaptobrevin 2; VAMP2) EBNA-2 co-activator (100 kD; p100) Thy-1 glycoprotein and Thy-1 co-transcribed protein Apolipoprotein L-II minor splice variant beta Golgi membrane sialoglycoprotein MG160 (LOC112781) esterase D/formylglutathione hydrolase (ESD) NADH dehydrogenase 1, clone IMAGE: 4120469 Prostaglandin D2 synthase (21 kD, brain) Phospholipase A2, group IIA9 platelets, synovial fliud (PLA2G2A) Glyceraldehyde-3-phosphate dehydrogenase (GAPD) Nicotinamide N-methyltransferase (NNMT) Lysyl oxidase-like 1 (LOXL1) A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit Ubiquitin specific protease 11 (USP11) NADH dehydrogenase 4, clone IMAGE: 4041417 Protein tyrosine phosphatase, receptor type, U (PTPRU) N-acetyltransferase, homolog of S. cerevisiae ARD1 (ARD1) ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21 kD (ATP6F) Glutathione S-transferase subunit 13 homolog (LOC51064) Malate dehydrogenase 2, NAD (mitochondrial; MDH2) Glutathione peroxidase 3 (plasma; GPX3) ATPase, Na+/K+ transporting, beta 3 polypeptide (ATP1B3) Phospholipase A2, group IIA (platelets, synovial fluid; PLA2G2A) Phosphodiesterase 6G, cGMP-specific, rod, gamma (PDE6G) CMP-NeuAC: (beta)-N-acetylgalactosaminide(alpha)2,6-sialyltransferase member VI (VI) Cytochrome c oxidase III, mRNA (MTCO3) Cytochrome c oxidase II, mRNA (MTCO2) Cytochrome c oxidase subunit VIb, Mrna (COX6B) Cytochrome c oxidase subunit Vb Humanin (HN1) Neutrophil gelatinase associated lipocalin (NGAL) Ferritin, light polypeptide (FTL) Ferritin, heavy polypeptide 1 (FTH1) BCL2-associated athanogene (BAG1) Cystatin C (amyloid angiopathy and cerebral hemorrhage; CST3) Ubiquitin-like protein smt3b (SENTRIN 2; H. sapiens; LOC96576) Channel proteins G protein pathway supressor 2 (GPS 2), transcript variant 3 S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light) Polypeptide (p11; S100A10) S100 calcium-binding protein A13 Cytoskeleton myosin regulatory light chain 2, smooth muscle isoform (MYL2) myosin, light polypeptide 6, alkali, smooth muscle and non-muscle (MYL6) actinin, alpha 1 (ACTN1) actin, beta (ACTB) keratin 13 (KRT13) Extracellular matrix laminin, beta 1 (LAMB1) collagen, type X, alpha 1 (COL10A1) crystallin, alpha A (CRYAA) integrin, beta 5 (ITB5) Vimentin (VIM) Tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor; TIMP1) Human biglycan BGN Syndecan-1 gene (exon 2-5; SDC1) Transgelin (TAGLN) Fibulin 1 (FBLN1) Actinin, alpha 1 (ACTN1) Fibulin-1 isoform D precursor Decorin (DCN) Actin, beta (ACTB) Fibromodulin (FMOD) Matrix Gla protein (MGLAP) Proline arginine-rich end leucine-rich repeat protein (PRELP) Kinase/phosphatase Pyruvate kinase, muscle, mRNA (PK3) Pyruvate kinase, muscle (PKM2) RET gene PPARA gene Neuronal specific GABA(A) receptor-associated protein (GABARAP) Protein processing/trafficking Phospholipid transfer protein (PLTP) Heat shock protein 105 kD (HSP 105 B) Ribonuclease, Rnase A family, 1 (pancreatic; RNASE1) Protein phosphatase 1, regulatory subunit 10 (PPP1R10) Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 (HERPUD1) Dynein, cytoplasmic, light intermediate polypeptide 2 (DNCLI2) Proteolysis Protease, serine, 11 (IGF binding; PRSS11) Proteasome (prosome, macropain) subunit, beta type, 7 (PSMB7) Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (PSMD4) Cathepsin D (lysosomal aspartyl protease; CTSD) RNA processing Small nuclear ribonucleoprotein D2 polypeptide (916.5 kD; SNRPD2) U6 snRNA-associated Sm-like protein (LSM2) Phenylalanyl-tRNA synthetase beta-subunit Clone 11 pur alpha-associated ribosomal RNA gene Serum/blood cell proteins Allograft inflammatory factor 1 (AIF1) Antigen identified by monoclonal antibodies 12E7, F21 and O13 Meningioma expressed antigen 5 (hyaluronidase; MGEA5) Retinol-binding protein 4, plasma (RBP4) Ig Kappa (IGKC) IgM heavy chain (IGHM) (fetal) Rearranged IgM chain VDJ-region Immunoglobulin gamma heavy chain (T6J/g) (hybridoma H210) Anti-hepatitis A IgG variable region Immunoglobulin heavy constant gamma 3 (G3m marker; IGH3) Clone 23u-1 immunoglobulin heavy chain variable region (IGH) Partial mRNA for immunoglobulin heavy chain constant region gamma 4 (IGHG4 gene) Myeloma immunoglobulin heavy chain Fd region V-D-J-CH1 Clone CAZ immunoglobulin light chain variable region gene Ig lambda light chain variable region gene (17-25OIVG7) Rearranged; Ig-Light-Lambda; V lambda Major histocompatibility complex, class I HLA-Bw62 3' end Major histocompatibility complex, class II, DP beta 1 (HLA-DPB1) HLA-A gene, HLA-A24 allele (HLA-A) T-cell gamma receptor locus Signaling molecules/growth factors/receptors Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) Interleukin enhancer binding factor 3, 90 kD (ILF3) Insulin-like growth factor binding protein 6 (IGFBP6) Signal recognition particle 72 kD (SRP72) Double stranded RNA activated protein kinase (PKR) gene, 3' flanking region Human lymph homing receptor (Lnhr) Stratifin (SFN) Regulator of G-protein signaling-16 (RGS16) gene Transcription/nuclear-specific proteins transcription factor (SMIF gene) ZNF gene family member (ZNF) zinc finger protein 106 (ZFP106) zinc finger protein 16 (KOX 9) nucleolar phosphoprotein p130 high-mobility group (nonhistone chromosomal) protein isoforms I and Y (HMGIY) KRAB-associated protein 1 (TIF1B) similar to leucine-zipper protein FKSG13 putative nucleolar RNA helicase (NOH61) NADH-ubiquinone oxidoreductase AGGG subunit precursor (nuclear gene encoding mitochondrial protein) LMO1 gene Testis enhanced gene transcript (TEGT) Translation/protein synthesis Eukaryotic translation intiation factor 3, subunit 8 (110 kD; EIF3S8) Eukaryotic translation elongation factor 1 gamma (EEF1G) Eukaryotic translation elongation factor 1 alpha 1, (EEF?) Interferon regulatory factor 3 (IRF3) Very long-chain acyl-CoA synthetase homolog 2 (VLCS-H2) Ribosomal protein L4 Ribosomal protein L8 Ribosomal protein L10 Ribosomal protein L11 Ribosomal protein L12 Ribosomal protein L13 Ribosomal protein L13a Ribosomal protein L18 Ribosomal protein L19 Ribosomal protein L21 Ribosomal protein L26 Ribosomal protein L29 Ribosomal protein L41 Ribosomal protein, large P2 Ribosomal protein S2 Ribosomal protein S6 Ribosomal protein S8 Ribosomal protein S9 Ribosomal protein S10 Ribosomal protein S18 Ribosomal protein S24 Ribosomal protein S25 Miscellaneous ADP-ribosylation factor 3 (ARF3) Small EDRK-rich factor 2 (SERF2) TRIAD3 protein Sex-regulated protein janus-a CD151 antigen Interferon induced transmembrane protein 3 (1-8U) Interferon induced transmembrane protein 1 (9-27) Clusterin (complement lysis inhibitor, SP-40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, polipoprotein J; CLU) Membrane protein of cholinergic synaptic vesicles (VATI) Adaptor protein complex AP-2, mu1 30 kDa protein (LOC55831) DnaJ (Hsp40) homolog, subfamily B, member 12 (DNAJB12) Signal recognition particle 14 kD (homologous Alu RNA-binding protein; SRP14) CpG island DNA genomic Mse fragment 1 Sequestosome 1 (SQSTM1) Keratin 13 (KRT13) ETV6 gene Thioredoxin, mitochondrial Complement component 3 (C3) Alpha 1,2-mannosidase Displacement loop (D-loop) region of human KB cell mitochondrion with adjoining part of tRNA genes Haptoglobin (HP) CD14 antigen Unknown function Homoer-3B protein DKFZP586A0522 protein (DKFZP586A0522) HNOEL-iso protein (HNOEL-iso) SNC73 protein (SNC73) Transmembrane adapter protein KAP10 (KAP10) Sestrin 2 (SES2) Sedum sediforme maturase K (matK) Prothymosin, alpha (gene sequence 28) Osa, clone IMAGE: 3866722 Dedicator of cyto-kinesis 3 (DOCK3) Transducer of ERBB2, 1 (TOB1) P1725 RIKEN cDNA 2810468K17 gene gC1qR/p32 gene Unknown (protein for MGC: 14173) Hypothetical genes KIAA0156 KIAA0174 KIAA0330 KIAA0443 KIAA0602 KIAA0738 KIAA0808 KIAA1029 KIAA1096 KIAA1249 KIAA1460 KIAA1716 ST5/L27a/KIAA0298 Hypothetical protein FLJ11749 H Hypothetical protein FLJ23277 Hypothetical glycine-rich protein [Mesorhizobium loti] Hypothetical protein FLJ20608 Hypothetical protein DKFZp761F241 Hypothetical protein, expressed in osteoblast (GS3686) Hypothetical protein RG083M05.2 Hypothetical protein FLJ22474 Hypothetical protein FLJ20327 Hypothetical protein FLJ10315 Hypothetical protein MGC10974 cDNA FLJ14538 fis cDNA FLJ10145 fis Hypothetical protein FLJ14154 Hypothetical protein FLJ14038 cDNA FLJ10158 fis Hypothetical gene ZD52F10 Hypothetical protein BC002942 cDNA: FLJ22128 fis cDNA: FLJ22803 fis Hypothetical protein MGC2491 Hypothetical protein FLJ13171 Hypothetical protein (LOC51059) Non-human Genes with Significant Homology to Human Sclera ESTs Mus musculus guanylate nucleotide binding protein 3 (Gbp3) Ortholog of mouse ZFP289 (ZFP289) Arabidopsis thaliana chromosome 5 Sprouty (Drosophila) homolog 4 (SPRY4) |