Table 2 of
Young, Mol Vis 2003;
9:508-514.
Table 2. Human scleral ESTs matched to known genes in GenBank and UniGene databases
The table lists known human genes identified among human scleral ESTs grouped according to (putative) function or cellular localization.
Clone
Putative identified protein and its gene symbol (if known)
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Cell cycle/proliferation/survival
Endothelial differentiation-related factor 1 (EDF1)
Lectin, galactoside-binding, soluble, 1 (galectin 1)
Cell surface markers/cell adhesion
Cerebral cell adhesion molecule (LOC51148)
Cellular metabolism
Milk fat globule-EGF factor 8 protein (MFGE8)
Nonmetastatic cells 2, protein (NM23B)
Apolipoprotein D gene, exon 4 (APOD)
Vesicle-associated membrane protein 2 (synaptobrevin 2; VAMP2)
EBNA-2 co-activator (100 kD; p100)
Thy-1 glycoprotein and Thy-1 co-transcribed protein
Apolipoprotein L-II minor splice variant beta
Golgi membrane sialoglycoprotein MG160 (LOC112781)
esterase D/formylglutathione hydrolase (ESD)
NADH dehydrogenase 1, clone IMAGE: 4120469
Prostaglandin D2 synthase (21 kD, brain)
Phospholipase A2, group IIA9 platelets, synovial fliud (PLA2G2A)
Glyceraldehyde-3-phosphate dehydrogenase (GAPD)
Nicotinamide N-methyltransferase (NNMT)
Lysyl oxidase-like 1 (LOXL1)
A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit
Ubiquitin specific protease 11 (USP11)
NADH dehydrogenase 4, clone IMAGE: 4041417
Protein tyrosine phosphatase, receptor type, U (PTPRU)
N-acetyltransferase, homolog of S. cerevisiae ARD1 (ARD1)
ATPase, H+ transporting, lysosomal (vacuolar proton pump) 21 kD (ATP6F)
Glutathione S-transferase subunit 13 homolog (LOC51064)
Malate dehydrogenase 2, NAD (mitochondrial; MDH2)
Glutathione peroxidase 3 (plasma; GPX3)
ATPase, Na+/K+ transporting, beta 3 polypeptide (ATP1B3)
Phospholipase A2, group IIA (platelets, synovial fluid; PLA2G2A)
Phosphodiesterase 6G, cGMP-specific, rod, gamma (PDE6G)
CMP-NeuAC: (beta)-N-acetylgalactosaminide(alpha)2,6-sialyltransferase member VI (VI)
Cytochrome c oxidase III, mRNA (MTCO3)
Cytochrome c oxidase II, mRNA (MTCO2)
Cytochrome c oxidase subunit VIb, Mrna (COX6B)
Cytochrome c oxidase subunit Vb
Humanin (HN1)
Neutrophil gelatinase associated lipocalin (NGAL)
Ferritin, light polypeptide (FTL)
Ferritin, heavy polypeptide 1 (FTH1)
BCL2-associated athanogene (BAG1)
Cystatin C (amyloid angiopathy and cerebral hemorrhage; CST3)
Ubiquitin-like protein smt3b (SENTRIN 2; H. sapiens; LOC96576)
Channel proteins
G protein pathway supressor 2 (GPS 2), transcript variant 3
S100 calcium-binding protein A10 (annexin II ligand, calpactin I, light)
Polypeptide (p11; S100A10)
S100 calcium-binding protein A13
Cytoskeleton
myosin regulatory light chain 2, smooth muscle isoform (MYL2)
myosin, light polypeptide 6, alkali, smooth muscle and non-muscle (MYL6)
actinin, alpha 1 (ACTN1)
actin, beta (ACTB)
keratin 13 (KRT13)
Extracellular matrix
laminin, beta 1 (LAMB1)
collagen, type X, alpha 1 (COL10A1)
crystallin, alpha A (CRYAA)
integrin, beta 5 (ITB5)
Vimentin (VIM)
Tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase
inhibitor; TIMP1)
Human biglycan BGN
Syndecan-1 gene (exon 2-5; SDC1)
Transgelin (TAGLN)
Fibulin 1 (FBLN1)
Actinin, alpha 1 (ACTN1)
Fibulin-1 isoform D precursor
Decorin (DCN)
Actin, beta (ACTB)
Fibromodulin (FMOD)
Matrix Gla protein (MGLAP)
Proline arginine-rich end leucine-rich repeat protein (PRELP)
Kinase/phosphatase
Pyruvate kinase, muscle, mRNA (PK3)
Pyruvate kinase, muscle (PKM2)
RET gene
PPARA gene
Neuronal specific
GABA(A) receptor-associated protein (GABARAP)
Protein processing/trafficking
Phospholipid transfer protein (PLTP)
Heat shock protein 105 kD (HSP 105 B)
Ribonuclease, Rnase A family, 1 (pancreatic; RNASE1)
Protein phosphatase 1, regulatory subunit 10 (PPP1R10)
Homocysteine-inducible, endoplasmic reticulum stress-inducible,
ubiquitin-like domain member 1 (HERPUD1)
Dynein, cytoplasmic, light intermediate polypeptide 2 (DNCLI2)
Proteolysis
Protease, serine, 11 (IGF binding; PRSS11)
Proteasome (prosome, macropain) subunit, beta type, 7 (PSMB7)
Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 (PSMD4)
Cathepsin D (lysosomal aspartyl protease; CTSD)
RNA processing
Small nuclear ribonucleoprotein D2 polypeptide (916.5 kD; SNRPD2)
U6 snRNA-associated Sm-like protein (LSM2)
Phenylalanyl-tRNA synthetase beta-subunit
Clone 11 pur alpha-associated ribosomal RNA gene
Serum/blood cell proteins
Allograft inflammatory factor 1 (AIF1)
Antigen identified by monoclonal antibodies 12E7, F21 and O13
Meningioma expressed antigen 5 (hyaluronidase; MGEA5)
Retinol-binding protein 4, plasma (RBP4)
Ig Kappa (IGKC)
IgM heavy chain (IGHM)
(fetal) Rearranged IgM chain VDJ-region
Immunoglobulin gamma heavy chain (T6J/g)
(hybridoma H210) Anti-hepatitis A IgG variable region
Immunoglobulin heavy constant gamma 3 (G3m marker; IGH3)
Clone 23u-1 immunoglobulin heavy chain variable region (IGH)
Partial mRNA for immunoglobulin heavy chain constant region gamma 4 (IGHG4 gene)
Myeloma immunoglobulin heavy chain Fd region V-D-J-CH1
Clone CAZ immunoglobulin light chain variable region gene
Ig lambda light chain variable region gene (17-25OIVG7)
Rearranged; Ig-Light-Lambda; V lambda
Major histocompatibility complex, class I HLA-Bw62 3' end
Major histocompatibility complex, class II, DP beta 1 (HLA-DPB1)
HLA-A gene, HLA-A24 allele (HLA-A)
T-cell gamma receptor locus
Signaling molecules/growth factors/receptors
Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)
Interleukin enhancer binding factor 3, 90 kD (ILF3)
Insulin-like growth factor binding protein 6 (IGFBP6)
Signal recognition particle 72 kD (SRP72)
Double stranded RNA activated protein kinase (PKR) gene, 3' flanking region
Human lymph homing receptor (Lnhr)
Stratifin (SFN)
Regulator of G-protein signaling-16 (RGS16) gene
Transcription/nuclear-specific proteins
transcription factor (SMIF gene)
ZNF gene family member (ZNF)
zinc finger protein 106 (ZFP106)
zinc finger protein 16 (KOX 9)
nucleolar phosphoprotein p130
high-mobility group (nonhistone chromosomal) protein isoforms I and Y (HMGIY)
KRAB-associated protein 1 (TIF1B)
similar to leucine-zipper protein FKSG13
putative nucleolar RNA helicase (NOH61)
NADH-ubiquinone oxidoreductase AGGG subunit precursor
(nuclear gene encoding mitochondrial protein)
LMO1 gene
Testis enhanced gene transcript (TEGT)
Translation/protein synthesis
Eukaryotic translation intiation factor 3, subunit 8 (110 kD; EIF3S8)
Eukaryotic translation elongation factor 1 gamma (EEF1G)
Eukaryotic translation elongation factor 1 alpha 1, (EEF?)
Interferon regulatory factor 3 (IRF3)
Very long-chain acyl-CoA synthetase homolog 2 (VLCS-H2)
Ribosomal protein L4
Ribosomal protein L8
Ribosomal protein L10
Ribosomal protein L11
Ribosomal protein L12
Ribosomal protein L13
Ribosomal protein L13a
Ribosomal protein L18
Ribosomal protein L19
Ribosomal protein L21
Ribosomal protein L26
Ribosomal protein L29
Ribosomal protein L41
Ribosomal protein, large P2
Ribosomal protein S2
Ribosomal protein S6
Ribosomal protein S8
Ribosomal protein S9
Ribosomal protein S10
Ribosomal protein S18
Ribosomal protein S24
Ribosomal protein S25
Miscellaneous
ADP-ribosylation factor 3 (ARF3)
Small EDRK-rich factor 2 (SERF2)
TRIAD3 protein
Sex-regulated protein janus-a
CD151 antigen
Interferon induced transmembrane protein 3 (1-8U)
Interferon induced transmembrane protein 1 (9-27)
Clusterin (complement lysis inhibitor, SP-40, sulfated glycoprotein 2,
testosterone-repressed prostate message 2, polipoprotein J; CLU)
Membrane protein of cholinergic synaptic vesicles (VATI)
Adaptor protein complex AP-2, mu1
30 kDa protein (LOC55831)
DnaJ (Hsp40) homolog, subfamily B, member 12 (DNAJB12)
Signal recognition particle 14 kD (homologous Alu RNA-binding protein; SRP14)
CpG island DNA genomic Mse fragment 1
Sequestosome 1 (SQSTM1)
Keratin 13 (KRT13)
ETV6 gene
Thioredoxin, mitochondrial
Complement component 3 (C3)
Alpha 1,2-mannosidase
Displacement loop (D-loop) region of human KB cell mitochondrion with adjoining part
of tRNA genes
Haptoglobin (HP)
CD14 antigen
Unknown function
Homoer-3B protein
DKFZP586A0522 protein (DKFZP586A0522)
HNOEL-iso protein (HNOEL-iso)
SNC73 protein (SNC73)
Transmembrane adapter protein KAP10 (KAP10)
Sestrin 2 (SES2)
Sedum sediforme maturase K (matK)
Prothymosin, alpha (gene sequence 28)
Osa, clone IMAGE: 3866722
Dedicator of cyto-kinesis 3 (DOCK3)
Transducer of ERBB2, 1 (TOB1)
P1725
RIKEN cDNA 2810468K17 gene
gC1qR/p32 gene
Unknown (protein for MGC: 14173)
Hypothetical genes
KIAA0156
KIAA0174
KIAA0330
KIAA0443
KIAA0602
KIAA0738
KIAA0808
KIAA1029
KIAA1096
KIAA1249
KIAA1460
KIAA1716
ST5/L27a/KIAA0298
Hypothetical protein FLJ11749 H
Hypothetical protein FLJ23277
Hypothetical glycine-rich protein [Mesorhizobium loti]
Hypothetical protein FLJ20608
Hypothetical protein DKFZp761F241
Hypothetical protein, expressed in osteoblast (GS3686)
Hypothetical protein RG083M05.2
Hypothetical protein FLJ22474
Hypothetical protein FLJ20327
Hypothetical protein FLJ10315
Hypothetical protein MGC10974
cDNA FLJ14538 fis
cDNA FLJ10145 fis
Hypothetical protein FLJ14154
Hypothetical protein FLJ14038
cDNA FLJ10158 fis
Hypothetical gene ZD52F10
Hypothetical protein BC002942
cDNA: FLJ22128 fis
cDNA: FLJ22803 fis
Hypothetical protein MGC2491
Hypothetical protein FLJ13171
Hypothetical protein (LOC51059)
Non-human Genes with Significant Homology to Human Sclera ESTs
Mus musculus guanylate nucleotide binding protein 3 (Gbp3)
Ortholog of mouse ZFP289 (ZFP289)
Arabidopsis thaliana chromosome 5
Sprouty (Drosophila) homolog 4 (SPRY4)
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