Figure 7 of Maddala, Mol Vis 2003; 9:329-336.

Figure 7. Lovastatin and C3-exoenzyme prevent growth factor-induced cytoskeletal reorganization

Pretreatment of lens epithelial cells with either C3-exoenzyme, a specific inhibitor of Rho GTPase, or lovastatin, a general isoprenylation inhibitor, abolished EGF, FGF and PDGF induced actin cytoskeletal reorganization. As in the case of Rho kinase inhibitor treated cells, C3-treated cells appear flat with no cortical rigidity but still maintained cell-cell contacts, while lovastatin treated cells underwent significant change in cell shape and appear rounded. Cells in this figure were stained only for F-actin, with rhodamin-phalloidin.

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Maddala, Mol Vis 2003; 9:329-336 <>
©2003 Molecular Vision <>
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