Figure 1. Schematic representation of the 5'-region of the mimecan gene

The positions of IFN-responsive regulatory elements, conserved E-box and p53 DNA-binding sites are indicated. The translation initiation start site (ATG), numbered with +1, is indicated in human and bovine exon 2. Alternative splicing sites within the second exon of human and bovine mimecan genes are indicated with white lines. The white rectangle within the arrow that marks the p53-binding site indicates the presence of additional half p53-binding sites in the bovine promoter.