Figure 4. Light-dependent distribution of transducin α subunit (Tα)

In dark-adapted state (left panels), the majority of Tα is distributed within rod outer segments (ROS), while in the light (right panels), a significant amount of Tα is localized to rod inner segments (RIS) and outer plexiform layer (OPL). The distribution of Tα in Grk1^-/-/Arr^-/- mice is indistinguishable from that of the wild type mice. A: Wild type (wt) mice. B: Grk1^-/-/Arr^-/- mice. ONL, outer nuclear layer. Bar represents 40 μm.