Figure 2. The light-dependent distribution of rod arrestin in dark- and light-adapted retinas

Independent of the genetic background, rod arrestin is predominantly localized in the rod inner segments (RIS) and outer plexiform layer (OPL) in the dark. In the light, however, the majority of rod arrestin is localized to rod outer segments (ROS). A: Wild type (wt) retinas. B: GRK1 knockout (Grk1^-/-) retinas. C: GRK1/Gnat1 double knockout (Grk1^-/-/Gnat1^-/-) mice. ONL, outer nuclear layer. Bar represents 40 μm.