Figure 3 of Bowne, Mol Vis 2003; 9:129-137.


Figure 3. Alignment of human and mouse RP1L1 sequences

The mouse sequence lacks the polymorphic repeat and low complexity repeat found in human RP1L1. The doublecortin and RP1 regions of the proteins are designated with solid bars.

                                            DC domain 1 -->
human   MNSTP---RNAQAP-----SHRECFLPSVARTPSVTKVTPAKKITFLKRGDPRFAGVRLA   52
mouse   MNSTPGDTRDAPAPSHPAPSHRQCLLPSVAHTPSVTEVTPAKKITFLKRGDPQFAGVRLA   60
        *****   *:* **     ***:*:*****:*****:***************:*******

human   VHQRAFKTFSALMDELSQRVPLSFGVRSVTTPRGLHSLSALEQLEDGGCYLCSDKKPPKT  112
mouse   VHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRKPPKT  120
        ****:*****:********:****************.*******:*********:*****

                                             DC domain 1 -->
human   PSGPGRPQERNPTAQQLRDVEGQREAPGTSSSRKSLKTPRRILLIKNMDPRLQQTVVLSH  172
mouse   SREPGRLQRKSPSAGQAQVFQGGHEAPETSYSWKGPVAPRRLTLVKNGDPRRQQTVVLSH  180
        .  *** *.:.*:* * : .:* :*** ** * *.  :***: *:** *** ********

human   RNTRNLAAFLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLVCAGHEAFRTPAMKN  232
mouse   KNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEAFRCLEMEN  240
        :***.*********:********:*** ********:**..********:****   *:*

human   ARRSEAETLSGLTSRNKNGSWGPKTKPSVIHSRSPPGSTPRLP----ERPGPSNPPVG--  286
mouse   DRGNRTRKLSSVTARSERGCWGPNAKQSVIHSRGRSGGKLRQVSLTSERSGLSDHPASGH  300
         * ..:..**.:*:*.:.*.***::* ******. .*.. *      **.* *: *..

                                 RP1 domain -->
human   -----PAPGRHPQDTPAQSGPLVAGDDMKKKVRMNEDGSLSVEMKVRFHLVGEDTLLWSR  341
mouse   RAWAGPALDRCPQDMPVPPGSLVAADDVEKKVCMNEDGSLSVEMKVRFQLLGEDTLRWSQ  360
             ** .* *** *. .*.***.**::*** ***************:*:***** **:

human   RMGRASALTAASGEDPVLGEVDPLCCVWEGYPWGFSEPGVWGPRPCRVGCREVFGRGGQP  401
mouse   RVGQASVFTAASGKGQDPREADRFCCRQEGYPWGILKPGAQGLGSYDGGCQEAFDVGQKS  420
        *:*:**.:*****:.    *.* :**  ******: :**. *  .   **:*.*. * :.

human   GPKYEIWTNPLHASQGERVAARKRWGLAQHVRCSGLWGHGTAGRERCSQDSASPASSTGL  461
mouse   QPSYDIWRNPLATPEGTGPTPRRRWGLAKLSGCKSHWRQEANHRKGHDKDNLSRVSTPRH  480
         *.*:** *** :.:*   :.*:*****:   *.. * : :  *:  .:*. * .*:.

human   PEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRL  521
mouse   PRSVQP-GSCCPWTPDGDTGSDTLHPVSSASSHNETDLESGEGLCLEDTGPHGSR-----  534
        *.. :* .**** **:....* :  .  .*. :   .* .. ***::.:*  *..

human   TPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPASPALSL  581
mouse   -PETQSTERALSDTSVSAKSREESSEGGGQLHRSSSQARVMASREQVTKGDNPCISTQSH  593
         *.::* * * **:*.*: *:* *** **: : ...:**. :*:::.::*.:*. .: *

human   SSLRSDDLQAETQGQGTE--QATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQR  639
mouse   LPLNHMGLQTEKYRQGTRGWEVSGEPELRLALVPGHSGSQDTQRDALPAPACAPAQWRQR  653
         .*.  .**:*.  ***.  :.:* .  * .** * * * *::  : ...:*:.:*  **

human   RHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDG  699
mouse   KQKRPASVECLPSVSVPYQVAQKGHARQDHYYRDTQSSLDT--ALQMPMPQEREQACPGS  711
        :::  **. . ** .   :** :**.*:.** :**:*.**:  : *:* * **.:** ..

human   SVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPS  759
mouse   PAPQSPSNSPSAGNQASEDLRSPFSSSLDLQEPQATSKATTIAVSGSDCVC----HSTRS  767
        ..*: ...*.*: .*** :**.* *.**  *:  .**.**. ..  ** *.    *.: *

human   AGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASPGEEARDTPQPSSPLVLQVGRPEQGAVG  819
mouse   VEPAGDTKCQAHSSTPTPAHRGELG------CLWDKAGTTPEPFSFSVLLDRCPEADDPR  821
        .  ***: .:: *.:* *.* .:        .  ::*  **:* *  **    ** .

human   PHRSHCCSQPGTQPAQEAQRGPSP----EASWLCGRYCPTPPRGRPCPQRRSSSCGSTGS  875
mouse   TYHDCCCLQAVPSSPLAAPSGQTQTSISEACLGGSSFCPTPPKEQTCFGRESASNGST-S  880
        .::. ** *. ....  *  * :     **.   . :*****: :.*  *.*:* *** *

human   SHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQ  935
mouse   SGHSRADGFAGP---------------------RRTLLVKSPGVRGSLEE----------  909
        * :* * * .*.                     **:   :..* **  **

human   GQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPG  995
mouse   -READGGVTPSALPYASPDAVVREWLGNIPEKPVLMTYEMADENTEVPSDGPEGPKED--  966
         :*  .**:**:** :**:*******.****:*:*****:***.* ....* .**: *

human   DDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAP 1055
mouse   ---SLKVLGEPSQAKQQPPEGATNEHPEPAGVLSGPGSVCCRLGGDLHPDATSGERLKAP 1023
           **: ****:** **. ** ..:.*** *.* *....  : * .:  .*:.    :**

human   AEAGADREAPAGCRVSLRALPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSA 1115
mouse   AEAGIGEGARVDHGVSLCALPTKVAASTQIMKALLGSKPGRPSSLPEVSSTVAQRLSSSA 1083
        **** .. * ..  *** *** :*:******:**:*** *****:**** .:*:***.**

human   GALITCLASLQLFEEDLGSPASKVRFKDSPWYQELLSISKDLWPGCDVGEDQLDSGLWEL 1175
mouse   GAFIACLARLHFFDESLGPLDGKVRLEESPKYQEMLRLFQTLWPGSELWQGQLDFSLRKL 1143
        **:*:*** *::*:*.**.  .***:::** ***:* : : ****.:: :.*** .* :*

human   TWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTS 1235
mouse   TSHQAL--LG----TEDFTPTSSSGVDVSSGSGGSGESSVPCVMDNTLAPEKRDLPLKIP 1197
        *  ***  **    **:**********:**************.**.**..:  :**** .

human   NQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAEN 1295
mouse   SQRPDSRNQGYPELVGHSTVSSVSQVR-----ACATGGEETGKGGRKQTWGNAPEQSVHS 1252
        .******.   *  : :.  .... .      ****. :*: :...:*  ..  ** ...

human   TVQEEVQLEETKEGTEGEGLQEEGVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQ 1355
mouse   TMLEGDALSEETEGRVRERLQEN------------------------------------- 1275
        *: *   *.* .**   * ***:

human   LEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASS 1415
mouse   -----SVHGKGLPEEGVR-------------------------------VCSQEMLAAGS 1299
             .. *:** ****:                               * .**:  *.*

human   PDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASESQSGSQLEP 1475
mouse   QDGAGSPEDTRVPTDEAGADAASGGLWPLDGREEPTESPQHFSESNSRVREHQSAHKLEL 1359
         ** ** **  *  :***  :**.   * :* *****.*.*:**::. . * **. :**

human   GLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLA 1535
mouse   GLEEVSRLDARGCKQACIKASSG------TMAHKGSLDPDPIWVSKLLKKIEKAFMAHLA 1413
        ***: .     * :::  :.:.*      ::* ..:** ****** **** ****:****

human   SAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREAL 1595
mouse   DATAELRARWDLHDNHLLDQMVTELEQDVGRRLQASTVMEVRKIQSRAGRMVPEPPREAL 1473
        .*.*******.*:**.*****.:**:***.:*** **  *::*:*.****** *******

human   TGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEE 1655
mouse   RGQASLQTEQRRRRLQGLRNFSAVP----GQGPLSLTLEDGPTLKTALGTKSGAEPAEDE 1529
         *:  ***:***:**:****:**..    * ****:**** *:*.****:: * *.  :*

human   FCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVXPGKT-- 1713
mouse   FCPCEICLKKKRTPRFPKDAATVSGAPVRKAFDLQQILQSKKGGSSNREAMEVAPQRTGR 1589
        ***** *::** :*  ** :  .: .*:::********* *:*  :: ** ** * :*

human   HTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQERE 1773
mouse   MLSQEDLGTVQGADE------KQGLGVAEGEEGEGKQRLRAEEDPEILKTEG-------- 1635
          .  .  *****:       .** ** ***:***.***. ::**:: ::**

human   GKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAE 1833
mouse   ------------------------------------------------------------


human   GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETP 1893
mouse   -------SGCCAPEED-------------------------------------------- 1644
               .* . **.:

human   EAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEEAQEAEGQ 1953
mouse   -----------------------------------------------EATEEDGEICIGT 1657
                                                       : :**:.: . *

human   AQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAE 2013
mouse   AQ---------------------------------------------------------- 1659
        **

human   EEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE 2073
mouse   -------------------ESQQLEGTEMGKEGTLP------------------------ 1676
                           *:*::**    .**

human   AEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIE 2133
mouse   ----------------------------------QSFRDGGTLEAPARQGTHS------- 1695
                                           . :..  :***  :*  .

human   APEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEKEAQPELEGVEAPEAEGEAQPES 2193
mouse   ------------------------------------------------------------


human   EGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESGGETQGEKKGSP 2253
mouse   ----------------------------------VEIQEASRERQQEVEGRHQDVKEDSP 1721
                                          **  **. * * *  *. *. *:.**

human   QVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKD 2313
mouse   WVSSGESQGRVGSENTSLDQEGRLLNHHQRPGPQSHHTACSSRALSLDNSSQVS---QKG 1778
         ** *:.*.. .**.:*   *.*     .  *  .*: . *. . * ..:*. .   **.

human   SENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQ 2373
mouse   SDGDLTSGDLKCTKAKNSRVLHAEKKVPVMYPERSSSEQE-VPSSPRLPKQGKGE----- 1832
        *:.* . ** :...**.: . ***:*.. **** *:**** .* ..* *:** .*

human   EDQALGSLAPTEAVGRADGFGQDDLDF 2400
mouse   DEGSAGSLACTQVGGKVDGFGQDDLDF 1859
        :: : **** *:. *:.**********

Bowne, Mol Vis 2003; 9:129-137 <http://www.molvis.org/molvis/v9/a19/>
©2003 Molecular Vision <http://www.molvis.org/molvis/>
ISSN 1090-0535