Figure 3 of
Bowne, Mol Vis 2003;
9:129-137.Figure 3 of
Bowne, Mol Vis 2003;
9:129-137.
Figure 3. Alignment of human and mouse RP1L1 sequences
The mouse sequence lacks the polymorphic repeat and low complexity repeat found in human RP1L1. The doublecortin and RP1 regions of the proteins are designated with solid bars.
DC domain 1 -->
human MNSTP---RNAQAP-----SHRECFLPSVARTPSVTKVTPAKKITFLKRGDPRFAGVRLA 52
mouse MNSTPGDTRDAPAPSHPAPSHRQCLLPSVAHTPSVTEVTPAKKITFLKRGDPQFAGVRLA 60
***** *:* ** ***:*:*****:*****:***************:*******
human VHQRAFKTFSALMDELSQRVPLSFGVRSVTTPRGLHSLSALEQLEDGGCYLCSDKKPPKT 112
mouse VHQRTFKTFSSLMDELSQRMPLSFGVRSVTTPRGLHGLSALEQLQDGGCYLCSDRKPPKT 120
****:*****:********:****************.*******:*********:*****
DC domain 1 -->
human PSGPGRPQERNPTAQQLRDVEGQREAPGTSSSRKSLKTPRRILLIKNMDPRLQQTVVLSH 172
mouse SREPGRLQRKSPSAGQAQVFQGGHEAPETSYSWKGPVAPRRLTLVKNGDPRRQQTVVLSH 180
. *** *.:.*:* * : .:* :*** ** * *. :***: *:** *** ********
human RNTRNLAAFLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLVCAGHEAFRTPAMKN 232
mouse KNTRSLAAFLGKASELLRFPVKQVYTTRGKKVDSLQTLLDGPSVLVCAGNEAFRCLEMEN 240
:***.*********:********:*** ********:**..********:**** *:*
human ARRSEAETLSGLTSRNKNGSWGPKTKPSVIHSRSPPGSTPRLP----ERPGPSNPPVG-- 286
mouse DRGNRTRKLSSVTARSERGCWGPNAKQSVIHSRGRSGGKLRQVSLTSERSGLSDHPASGH 300
* ..:..**.:*:*.:.*.***::* ******. .*.. * **.* *: *..
RP1 domain -->
human -----PAPGRHPQDTPAQSGPLVAGDDMKKKVRMNEDGSLSVEMKVRFHLVGEDTLLWSR 341
mouse RAWAGPALDRCPQDMPVPPGSLVAADDVEKKVCMNEDGSLSVEMKVRFQLLGEDTLRWSQ 360
** .* *** *. .*.***.**::*** ***************:*:***** **:
human RMGRASALTAASGEDPVLGEVDPLCCVWEGYPWGFSEPGVWGPRPCRVGCREVFGRGGQP 401
mouse RVGQASVFTAASGKGQDPREADRFCCRQEGYPWGILKPGAQGLGSYDGGCQEAFDVGQKS 420
*:*:**.:*****:. *.* :** ******: :**. * . **:*.*. * :.
human GPKYEIWTNPLHASQGERVAARKRWGLAQHVRCSGLWGHGTAGRERCSQDSASPASSTGL 461
mouse QPSYDIWRNPLATPEGTGPTPRRRWGLAKLSGCKSHWRQEANHRKGHDKDNLSRVSTPRH 480
*.*:** *** :.:* :.*:*****: *.. * : : *: .:*. * .*:.
human PEGSEPESSCCPRTPEDGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRL 521
mouse PRSVQP-GSCCPWTPDGDTGSDTLHPVSSASSHNETDLESGEGLCLEDTGPHGSR----- 534
*.. :* .**** **:....* : . .*. : .* .. ***::.:* *..
human TPRARSEEGASSDSSASTGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPASPALSL 581
mouse -PETQSTERALSDTSVSAKSREESSEGGGQLHRSSSQARVMASREQVTKGDNPCISTQSH 593
*.::* * * **:*.*: *:* *** **: : ...:**. :*:::.::*.:*. .: *
human SSLRSDDLQAETQGQGTE--QATGAAVTREPLVLGLSCSWDSEGASSTPSTCTSSQQGQR 639
mouse LPLNHMGLQTEKYRQGTRGWEVSGEPELRLALVPGHSGSQDTQRDALPAPACAPAQWRQR 653
.*. .**:*. ***. :.:* . * .** * * * *:: : ...:*:.:* **
human RHRSRASAMSSPSSPGLGRVAPRGHPRHSHYRKDTHSPLDSSVTKQVPRPPERRRACQDG 699
mouse KQKRPASVECLPSVSVPYQVAQKGHARQDHYYRDTQSSLDT--ALQMPMPQEREQACPGS 711
::: **. . ** . :** :**.*:.** :**:*.**: : *:* * **.:** ..
human SVPRYSGSSSSTRTQASGNLRPPSSGSLPSQDLLGTSSATVTPAVHSDFVSGVSPHNAPS 759
mouse PAPQSPSNSPSAGNQASEDLRSPFSSSLDLQEPQATSKATTIAVSGSDCVC----HSTRS 767
..*: ...*.*: .*** :**.* *.** *: .**.**. .. ** *. *.: *
human AGWAGDAGSRTCSPAPIPPHTSDSCSKSGAASPGEEARDTPQPSSPLVLQVGRPEQGAVG 819
mouse VEPAGDTKCQAHSSTPTPAHRGELG------CLWDKAGTTPEPFSFSVLLDRCPEADDPR 821
. ***: .:: *.:* *.* .: . ::* **:* * ** ** .
human PHRSHCCSQPGTQPAQEAQRGPSP----EASWLCGRYCPTPPRGRPCPQRRSSSCGSTGS 875
mouse TYHDCCCLQAVPSSPLAAPSGQTQTSISEACLGGSSFCPTPPKEQTCFGRESASNGST-S 880
.::. ** *. .... * * : **. . :*****: :.* *.*:* *** *
human SHQSTARGPGGSPQEGTRQPGPTPSPGPNSGASRRSSASQGAGSRGLSEEKTLRSGGGPQ 935
mouse SGHSRADGFAGP---------------------RRTLLVKSPGVRGSLEE---------- 909
* :* * * .*. **: :..* ** **
human GQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILMTYELADETTGAAGGGLRGPEVDPG 995
mouse -READGGVTPSALPYASPDAVVREWLGNIPEKPVLMTYEMADENTEVPSDGPEGPKED-- 966
:* .**:**:** :**:*******.****:*:*****:***.* ....* .**: *
human DDHSLEGLGEPAQAGQQSLEGDPGQDPEPEGALLGSSDTGPQSGEGVPQGAAPEGVSEAP 1055
mouse ---SLKVLGEPSQAKQQPPEGATNEHPEPAGVLSGPGSVCCRLGGDLHPDATSGERLKAP 1023
**: ****:** **. ** ..:.*** *.* *.... : * .: .*:. :**
human AEAGADREAPAGCRVSLRALPGRVSASTQIMRALMGSKQGRPSSVPEVSRPMARRLSCSA 1115
mouse AEAGIGEGARVDHGVSLCALPTKVAASTQIMKALLGSKPGRPSSLPEVSSTVAQRLSSSA 1083
**** .. * .. *** *** :*:******:**:*** *****:**** .:*:***.**
human GALITCLASLQLFEEDLGSPASKVRFKDSPWYQELLSISKDLWPGCDVGEDQLDSGLWEL 1175
mouse GAFIACLARLHFFDESLGPLDGKVRLEESPKYQEMLRLFQTLWPGSELWQGQLDFSLRKL 1143
**:*:*** *::*:*.**. .***:::** ***:* : : ****.:: :.*** .* :*
human TWSQALPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTS 1235
mouse TSHQAL--LG----TEDFTPTSSSGVDVSSGSGGSGESSVPCVMDNTLAPEKRDLPLKIP 1197
* *** ** **:**********:**************.**.**..: :**** .
human NQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAEN 1295
mouse SQRPDSRNQGYPELVGHSTVSSVSQVR-----ACATGGEETGKGGRKQTWGNAPEQSVHS 1252
.******. * : :. .... . ****. :*: :...:* .. ** ...
human TVQEEVQLEETKEGTEGEGLQEEGVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQ 1355
mouse TMLEGDALSEETEGRVRERLQEN------------------------------------- 1275
*: * *.* .** * ***:
human LEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASS 1415
mouse -----SVHGKGLPEEGVR-------------------------------VCSQEMLAAGS 1299
.. *:** ****: * .**: *.*
human PDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASESQSGSQLEP 1475
mouse QDGAGSPEDTRVPTDEAGADAASGGLWPLDGREEPTESPQHFSESNSRVREHQSAHKLEL 1359
** ** ** * :*** :**. * :* *****.*.*:**::. . * **. :**
human GLEKPPGATMMGQEHTQAQPTQGAAERSSSVACSAALDCDPIWVSVLLKKTEKAFLAHLA 1535
mouse GLEEVSRLDARGCKQACIKASSG------TMAHKGSLDPDPIWVSKLLKKIEKAFMAHLA 1413
***: . * ::: :.:.* ::* ..:** ****** **** ****:****
human SAVAELRARWGLQDNDLLDQMAAELQQDVAQRLQDSTKRELQKLQGRAGRMVLEPPREAL 1595
mouse DATAELRARWDLHDNHLLDQMVTELEQDVGRRLQASTVMEVRKIQSRAGRMVPEPPREAL 1473
.*.*******.*:**.*****.:**:***.:*** ** *::*:*.****** *******
human TGELLLQTQQRRHRLRGLRNLSAFSERTLGLGPLSFTLEDEPALSTALGSQLGEEAEGEE 1655
mouse RGQASLQTEQRRRRLQGLRNFSAVP----GQGPLSLTLEDGPTLKTALGTKSGAEPAEDE 1529
*: ***:***:**:****:**.. * ****:**** *:*.****:: * *. :*
human FCPCEACVRKKVSPMSPKATMGATRGPIKEAFDLQQILQRKRGEHTDGEAAEVXPGKT-- 1713
mouse FCPCEICLKKKRTPRFPKDAATVSGAPVRKAFDLQQILQSKKGGSSNREAMEVAPQRTGR 1589
***** *::** :* ** : .: .*:::********* *:* :: ** ** * :*
human HTDPTSTRTVQGAEGGLGPGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQERE 1773
mouse MLSQEDLGTVQGADE------KQGLGVAEGEEGEGKQRLRAEEDPEILKTEG-------- 1635
. . *****: .** ** ***:***.***. ::**:: ::**
human GKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAE 1833
mouse ------------------------------------------------------------
human GIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETP 1893
mouse -------SGCCAPEED-------------------------------------------- 1644
.* . **.:
human EAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEEAQEAEGQ 1953
mouse -----------------------------------------------EATEEDGEICIGT 1657
: :**:.: . *
human AQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAE 2013
mouse AQ---------------------------------------------------------- 1659
**
human EEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQE 2073
mouse -------------------ESQQLEGTEMGKEGTLP------------------------ 1676
*:*::** .**
human AEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIE 2133
mouse ----------------------------------QSFRDGGTLEAPARQGTHS------- 1695
. :.. :*** :* .
human APEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEKEAQPELEGVEAPEAEGEAQPES 2193
mouse ------------------------------------------------------------
human EGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESGGETQGEKKGSP 2253
mouse ----------------------------------VEIQEASRERQQEVEGRHQDVKEDSP 1721
** **. * * * *. *. *:.**
human QVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKD 2313
mouse WVSSGESQGRVGSENTSLDQEGRLLNHHQRPGPQSHHTACSSRALSLDNSSQVS---QKG 1778
** *:.*.. .**.:* *.* . * .*: . *. . * ..:*. . **.
human SENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQ 2373
mouse SDGDLTSGDLKCTKAKNSRVLHAEKKVPVMYPERSSSEQE-VPSSPRLPKQGKGE----- 1832
*:.* . ** :...**.: . ***:*.. **** *:**** .* ..* *:** .*
human EDQALGSLAPTEAVGRADGFGQDDLDF 2400
mouse DEGSAGSLACTQVGGKVDGFGQDDLDF 1859
:: : **** *:. *:.**********
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