Figure 2 of
Bowne, Mol Vis 2003;
9:129-137.Figure 2 of
Bowne, Mol Vis 2003;
9:129-137.
Figure 2. RP1L1 protein sequence
A: RP1L1 contains a region of homology to doublecortin (DC) and to RP1 (RP1). RP1L1 also contains a 16 amino acid polymorphism and large low complexity repeat. B: Comparison of the four shortest RP1L1 repeat polymorphisms. Repeat sequences are in red with an arrow depicted for each repeat. Sequence surrounding the repeats is very similar to that contained in one copy of the repeat. C: Partial alignment of human RP1L1 and RP1 protein sequences. The sequences corresponding to the doublecortin domains and RP1 domain are identified with bars. The asterisk ("*") represents identical amino acids and the period (".") represents similar amino acid residues.
B.
--------------->--------------->--------------->
XVQLEETKTEEGLQEEGVQLEETKTEEGLQEEGVQLEETKTEEGLQEEGVQLEGTKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEE
--------------->--------------->
XVQLEXTKTXEGLQEEGVQLEXTKTEEGLQEEGVQLEXTK................ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEE
--------------->
RVQLEETKTEEGLQEEGVQLEETK................................ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEE
XVQLEXTK................................................ETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEE
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C.
DC domain 1 -->
RP1L1 1 MNSTPRNAQXPSHRECFLPSVA--RTPSVTKVTPAKKITFLKRGDPRFAGVRLAVHQRAFKTFSALMDELSQRVP 73
RP1 1 MSDTPSTGFSIIHPTSSEGQVPPPRHLSLTHPVVAKRISFYKSGDPQFGGVRVVVNPRSFKSFDALLDNLSRKVP 75
* ** . * . * * *.*. **.*.* * ***.* ***. *. *.**.* **.* **..**
RP1L1 74 LSFGVRSVTTPRGLHSLSALEQLEDGGCYLCSD-KKPPKTPSGPGRPQERNPTAQQLRDVEGQREAPGTSSSRKS 147
RP1 76 LPFGVRNISTPRGRHSITRLEELEDGESYLCSHGRKVQPVDLDKARRRPR-PWLSSRAISAHSPPHPVAVAAPGM 149
* **** ..**** **.. **.**** .**** .* * . * * * . ..
DC domain 2 -->
RP1L1 148 LKTPRRILLIKNMDPRLQQTVVLSHRNTRNLAAFLGKASDLLRFPVKQLYTTSGKKVDSLQALLHSPSVLVCAGH 222
RP1 150 PRPPRSLVVFRNGDPKTRRAVLLSRRVTQSFEAFLQHLTEVMQRPVVKLYATDGRRVPSLQAVILSSGAVVAAGR 224
. ** ... .* **. ...*.**.* *. *** . ..... ** .**.* *..* ****.. * .*.**.
RP1L1 223 EAFRTPAMKNARRSEAETLSGLTSRNK-NGSWGPKTKPSVIHS----RS--PPGSTPRLPERPGPSNPPVGPAPG 290
RP1 225 EPFKPGNYDIQKYLLPARLPGISQRVYPKGNAKSESRKISTHMSSSSRSQIYSVSSEKTHNNDCYLDYSFVPEKY 299
* *. . * *.. * * .. * ** *. . *
RP1 domain -->
RP1L1 291 RHPQDTPAQSGPLVAG-DDMKKKVRMNEDGSLSVEMKVRFHLVGEDTLLWS 340
RP1 300 LALEKNDSQNLPIYPSEDDIEKSIIFNQDGTMTVEMKVRFRIKEEETIKWT 350
. . .* *. **. * . *.**...*******.. *.*. *.
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