Figure 2 of
Runkle, Mol Vis 2002;
8:45-50.Figure 2 of
Runkle, Mol Vis 2002;
8:45-50.
Figure 2. Alignment of several vertebrate aA-crystallin orthologues
The deduced zebrafish aA-crystallin peptide sequence was aligned with indicated vertebrate orthologues using the algorithm CLUSTAL W [29]. Shown are cavefish (Astyanax fasciatus, CAA72159), shark (Squalus acanthias, CYDFAA), amphibian (Rana catesbeiana, CAA59471), bird (Gallus gallus, 225741), and human (Homo sapiens, 1091617). Asterisks indicate amino acids identical to the zebrafish sequence. Dashes represent gaps introduced to optimize alignment.
Zebrafish 1 MDIAIQHPWFRRTLG--YPTRLFDQFFGEGLFDYDLFPFTTSTVSPYYRH Cavefish 1 ************A**--**S******************YA*********Y Shark 1 **L***Y*****S**SF**S*******************FS**I*****Q Amphibian 1 **********K*A**PF**N*****V****M********LS********* Bird 1 ***T******K*A**PLI*S***********LE***L*LFS**I*****Q Human 1 **VT******K*T**PF**S************E***L**LS**I*****Q Zebrafish 49 SLFRNILDSSNSGVSEVRSDREKFTVYLDVKHFSPDELSVKVTDDYVEIQ Cavefish 49 *****F*******M*******D**M**********E**N***AE****** Shark 51 *V***F***---*I*****EKDR*MIN*N******E*****IV******H Amphibian 51 ****GFM**---*I*******DR**IN*********D*T**IL**F***H Bird 51 ****SV*E*---*I*******D***IM********ED****II**F***H Human 51 ****TV***---*I*******D**VIF********ED*T***Q**F***H Zebrafish 99 GKHGERQDDHGYISREFHRRYRLPSNVDQSAITCTLSADGLLTLCGPKT- Cavefish 99 ****************************************Q**I****S- Shark 98 ***A***E*Q*RV******T*H****LNE***A*S**NE******C***R Amphibian 98 ***S**********************L***S*S*S*****I**FS***MM Bird 98 ***S********************A*********S**S**M**FS***VP Human 98 ***N***************************LS*S*****M**F****IQ Zebrafish 148 SGIDAGRGDRTIPVTREDKSNSGSSS---- Cavefish 148 G*SES*****S*****D**T**TP**---- Shark 148 P*D*SNWQ**P***S**E*QGTQPEIRADP Amphibian 148 **L*SSHSE*P***S**E*PT*AP**---- Bird 148 *NM*PSHSE*P***S**E*PT*AP**---- Human 148 T*L**THAE*A***S**E*PT*AP**---- |