Figure 5. P-glycoprotein activity in cultured human RPE

Rhodamine uptake was measured in cultured human RPE cell monolayers (cells at passages between 8 and 14) grown on 35 mm dishes. Rhodamine concentration was 20 μM. Reversin concentration was also 20 μM. Data are means±SEM. By paired t-test reversin 121 (p<0.001) and reversin 205 (p<0.001) significantly altered rhodamine content.