Table 1 of
Acharya, Mol Vis 2002;
8:367-371.Table 1 of
Acharya, Mol Vis 2002;
8:367-371.
Table 1. Genotype distribution and allelic frequencies of p53 codon 72 polymorphism in control subjects and POAG patients
Genotype Allele frequency
----------------------------------------------------- ----------------------------------------
Test Total number Total number
Group Arg/Arg Arg/Pro Pro/Pro of individuals Arg Pro of chromosomes
------- ---------- ---------- ---------- -------------- ---------- ---------- --------------
POAG 23 (34.3%) 30 (44.8%) 14 (20.9%) 67 (100%) 0.57 (76) 0.43 (58) 134
Control 30 (26.8%) 57 (50.9%) 25 (22.3%) 112 (100%) 0.52 (117) 0.48 (107) 224
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The genotype distribution of POAG patients were not significantly different from controls (χ2=1.150, degrees of freedom=2, p=0.5627). Similarly, there was no significant difference between the two groups in allelic distribution (χ2=0.559, degrees of freedom=1, p=0.4547). In the Chinese control group the genotype distribution is reported to be 42.3%, 44%, and 13.6% for Arg homozygote, Pro/Arg heterozygote and Pro homozygote, respectively. On the other hand, the distribution of the genotypes in the same order in Chinese POAG patients is 20.7%, 44.8%, and 34.5% [12].