Table 1 of
Escribano, Mol Vis 2002;
8:315-332.Table 1 of
Escribano, Mol Vis 2002;
8:315-332.
Table 1. Ciliary Body Subtracted (CBS) clones of known function
Classification of 179 subtracted ESTs expressed in the human ciliary body into 17 functional groups. Representative GenBank entries are shown along with chromosomal location and the number of ESTs identified using the BlastN program. Clones marked with an asterisk are 90 ESTs previously analyzed [1].
GenBank
GenBank accession
CBS accession number of
clone number of homologous
number CBS clones Putative identification clones Chromosome
------ ---------- -------------------------------------------------------- ---------- ----------
Neuronal, neuroendocrine, and phototransduction
140, R30676, Phospholipase C, beta 4 XM_009499 20p12.3
369* R47185
291 R36835 GABA (A) receptor-associated protein XM_113325 17p13.1
294* R36841 Carboxypeptidase E (CPE) XM_003479 4q32.3
659 R95485 Odd Oz/ten-m homolog 2 XM_047995 5q34
577 R95441 Synaptogyrin I XM_009999 22q13.1
390 R47196 SDR1, short-chain dehydrogenase/reductase 1 BC002730 1p36.21
Circadian rhythm proteins
15, R30638, SCN Circadian Oscillatory Protein- (SCOP) like XM_166290 18q21.33
18 R30640
203 R36797 Similar to acetylserotonin methytransferase-like protein BC010089 Xp22.3
Proteins involved in glaucoma
424, R47209, Myocilin AF001620 1q23.3
582, R95443,
591, R95447,
670 R95491
Protein synthesis (transcription, translation, and nuclear transport)
19* R30670 Nuclear p68 protein AF015812 17q23.3
180 R36789 Nuclear receptor subfamily 1, group mH, member 2 XM_046419 19q13.33
533 R88394 Nuclear receptor subfamily 2, group F, member 1 X12795 5q14.3
375 R47187 Retinoid X receptor, beta (RXRB) XM_042580 6p21.1
594 R95449 Nascent-polypeptide-associated complex alpha polypeptide AF054187 12q13.3
321* R45891 Thyroid hormone receptor c-erb-A X04707 3p24.2
648* R95477 Transcription factor 4 XM_028593 -
20 R30641 Butyrate response factor 1(EGF-response factor 1), XM_007458 14q24.1
zinc finger protein 36 C3H type-like 1
27* R30645 Inhibitor of DNA binding 2, dominant negative helix- AC090111 3p14.2
loop-helix protein
1 R30632 Pilin-like transcription factor AF151889 10p12.2
183* R36791 Pre-B-cell leukemia transcription factor 3 NM_006195 9q34.11
84* R30674 Transcription factor binding to IGHM enhancer 3 NM_006521 Xp11.22
194 R36795 Core-binding factor, runt domain, alpha subunit 2 XM_028366 16q24.2
590 R95446 Hypoxia-inducible factor 1, alpha subunit (basic AF050119 14q23.1
helix-loop-helix transcription factor)
318 R45889 ALL-1 (myeloid/lymphoid or mixed-lineage leukemia) Z69780 11q23.3
346 R45911 HSPCO33 Similar to 12kDa signal peptidase subunit NM_014041 3p21.1
447 R47219 H-2K binding factor-2 L08904 4p15.1
473* R88366 Ribosomal protein S27a AC012358 2p16.1
640 R95473 Human DNA for hnRNP protein A2/B1 D28877 7p15.2
222* R36806 Heterogeneous nuclear ribonucleoprotein H2 (H') XM_037713 Xq22.1
667 R95489 Heterogeneous nuclear ribonucleoprotein A0 BC012980 -
639 R95472 Eukaryotic translation initiation factor 3, U46025 16p12.3
subunit 8 (110kD) EIF3S8
66* R30672 Eukaryotic translation elongation factor 1, alpha1 BC014224 -
207 R36799 Small nuclear ribonucleoprotein D3 polypeptide XM_009884 2q11.23
380 R47188 Homo sapiens mitochondrial ribosomal protein XM_041727 6p21.33
S18B (MRPS18B)
557 R95432 Karyopherin (importin) beta 3 NM_002271 13q32.3
547 R88399 Sentrin 2, SMT3H2:SMT3 suppressor XM_041583 17q25
of mif two 3 homolog 2 (yeast)
Protein folding
293* R36840 Heat shock 90 kD protein 1, beta BC009206 6p21.1
147* R30669 Heat shock 70 kD protein 2 XM_012385 14q23.2
381, R47189, Heat shock 27 kD protein 1 NM_001540 7q11.23
634* R95469
458* R47224 Crystallin alpha B BC007008 11q23.2
527 R88392 Heat shock 70 kD protein 8 XM_050984 11q24.1,
7p21.3
519 R88389 Heat shock 70kD protein 1A XM_004188 6p21.32
317 R45888 FK506-binding protein 5 FKBP54 mRNA NM_004117 6p21.31
Secretion/vesicular trafficking
452 R47221 N-ethylmaleimide-sensitive factor BC001165 19q13.3
attachment protein, alpha
476 R88369 PDZK1 protein NM_002614 1q21.1
482 R88371 Coatomer alpha-subunit U24105 1q23.2
553 R95478 Copine I BC001142 20q11.22
570 R95440 Echinoderm microtubule-associated protein-like U97018 14q32.2
665 R95488 Signal recognition particle 9kD BC008443 1q42.12
419 R47207 Vesicle trafficking protein XM_048663 3p22.1
262 R36824 Vacuolar protein sorting 29 (yeast homolog) XM_027068 12q24.11
223* R36807 Rab geranylgeranyl transferase b subunit XM_038819 1p31.1
331 R45901 ADP-ribosylation factor-like 3 (ARL3) BC009841 10q24.32
65 R30660 PSCD3 Pleckstrin homology, Sec7 and coiled/coil domains 3 AK023609 7p22.1
Protein degradation, proteinases, and proteinase inhibitors
385 R47192 Ubiquitin specific protease 24 (USP24) XM_038934 1p32.3
494 R88378 Ubiquitin specific protease 11 XM_010378 Xp11.3
428 R47213 Homo sapiens E3 ubiquitin ligase SMURF1 (SMURF1) XM_052430 7q22.1
663 R95487 UBE3B Ubiquitin protein ligase AF251046 12q24.11
249 R36818 F-BOX domain protein mRNA AF248640 6q24.3
23* R30643 Homocysteine-inducible, endoplasmic reticulum NM_014685 16q13
stress-inducible, ubiquitin-like domain member 1, HERPUD1
418 R47206 Proteasome subunit z D38048 9q34.11
425 R47210 Proteasome subunit HC8, 5'-flanking region D21801 14q23.1
641 R95474 Proteasome 26S subunit, non-ATPase, 4 AB033605 1q21.1
560 R95479 Calpain 1 large subunit XM_045606 11q13.2
322* R45892 Protease, serine, 15 BC000235 -
334* R45904 Insulin-degrading enzyme M21188 10q23.33
620* R95463 Cathepsin O XM_041899 1q22
265 R36826 Cathepsin D NM_001909 11p15.5
16* R30639 α-2 Macroglobulin XM_006925 12p13.2
550* R95426 Tissue factor pathway inhibitor 2 AF217542 7q32.1
442 R47216 Tissue inhibitor of metalloproteinase 2 (TIMP-2) U44381 17q25.3
Cytoskeleton/contractility
308* R45883 Transgelin XM_052027 11q23.3
139* R36784 Myosin, heavy polypeptide 11, smooth muscle XM_027257 16p13.11
386 R47193 Filamin B, beta (actin-binding protein-278) XM_030804 3p14.3
51* R30653 Tubulin, beta polypeptide AF141349 6p21.33
82*, R30664, Actin, alpha 2, smooth muscle, aorta BC017554 10q23.31
498* R88379
513 R88386 Tropomyosin 1 (alpha) M19267 15q22.2
152*, R36785, Myosin, light polypeptide kinase XM_056766 3q21.1
427, R47212,
549 R88400
570 R95440 Echinoderm microtubule-associated protein/like NM_004434 14q32.2
464 R88360 Myosin phosphatase, target subunit 1 XM_006578 12q21.31
315* R45886 Profilin 1 XM_028378 -
188 R36838 Coactosin-like protein BC010039 16q24.1
329, R45899, Sarcoglycan, beta (43 kD dystrophin- XM_003553 4q12
333 R45903 associated glycoprotein)
37* R30671 Gelsolin XM_016545 9q33.3
552 R95428 Serine/threonine kinase with Dbl- and pleckstrin homology XM_003027 3q21.2
domains (TRAD)
462 R88359 BCL7A, putative F-actin cross linking protein 12 homolog X89985 7q11.22
253 R36821 Wiskott-Aldrich syndrome interacting AC010894 2q31.1
668 R95490 ROCK1: Rho-associated, coiled-coil - 18q11.1
containing protein kinase 1
Cell signaling/cell differentiation
181* R36790 Mitogen-activated protein kinase 2 NM_030662 19p13.3
269* R36828 Guanine nucleotide-binding protein Gsα BC008855 -
327* R45897 Regulator of G-protein signalling 2, 24kD BC007049 1q31.2
457 R47225 Guanine nucleotide binding protein 10 NM_004125 -
197* R36796 Homo sapiens RYK receptor-like tyrosine kinase NM_002958 16p13.2
319* R45890 Protein tyrosine phosphatase, receptor type, G L09247 3p14.2
105* R36782 Calmodulin 2 (phosphorylase kinase, delta) BC008437 -
471 R88364 Human frizzled-related protein U68057 -
67 R30673 Epithelial membrane protein 1 XM_042423 12p13.1
623 R95465 Homo sapiens similar to pleckstrin homology domain- XM_038280 2q31.2,
containing, family A (phosphoinositide 19q13.13
binding specific) member 3, PLEKHA3
534 R88395 Bone morphogenetic protein receptor, type IB - 4q22.3
Cell cycle/apoptosis
13* R30637 Proliferating-cell nucleolar protein p-120 XM_057819 12p13.31
221 R36805 Apoptosis related protein APR-3 XM_002429 2p23.2
276* R36830 Human guanine nucleotide regulatory protein (ABR) U01147 17p13.3
286* R36833 v-erb-b2 avian erythroblastic leukemia viral oncogene XM_049823 17q21.1
homolog 2 (neuro/glioblastoma derived oncogene homolog)
213 R36802 Cyclin-dependent kinase inhibitor 1B XM_006894 12p13.2
389* R47195 TRPM-2 (clusterin) XM_053980 8p21.1
Immune-related proteins
6* R30635 Complement component C4 NM_000592 6p21.32
21* R30642 Mac-2 binding protein (lectin, galactoside-binding BC015761 17q25.3
soluble, 3 binding protein)
606* R95455 Peroxiredoxin 1 (natural killer-enhancing factor A) BC007063 1p34.1
143* R30668 MHC Class I BC007814 6p21.32
500* R88380 Macrophage-stimulating protein 16161795 -
617* R95461 Lipocortin X05908 9q21.11
241 R36812 Homo sapiens cDNA: FLJ23146 fis, - 11p13
clone LNG09293 highly similar,
to AC003689 Homo sapiens mRNA for T-cell glycoprotein CD6
361 R45919 CD24 antigen BC007674 6q21,
Yq11.222
Metabolism
523 R88390 Alpha-galactosidase BC002689 Xq22.1
237 R36810 Flavohemoprotein b5+b5R AF169803 6q15
635 R95470 Piruvate kinase, muscle BC007952 15q22
607* R95456 Creatine kinase isozyme CK-B X15334 14q32.32
461, R88358, Glyceraldehyde-3-phosphate dehydrogenase, testis specific XM_009352 19q13.11
480 R88401
252* R36820 Glyceraldehyde-3-phosphate dehydrogenase XM_033260 -
657 R95483 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 AF056320 10p14
295 R36837 Glyoxylate reductase/hydroxypyruvate reductase XM_042263 9p13.1
604* R95453 Farnesyl-diphosphate farnesyltransferase 1 XM_005134 8p23.1
488 R88374 Creatine kinase, brain X15334 X(14q32.32)
77* R30663 Phosphorylase kinase, alpha 1 (muscle) NM_002637 Xq13.3
492 R88377 ATP synthase, H+ transporting, mitochondrial F1 complex, XM_038872 18q21.1
alpha subunit, isoform 1, cardiac muscle
554* R95429 Glucose-6-phosphate dehydrogenase - -
555 R95430 Malic enzyme 1, NADP(+)-dependent, cytosolic (ME1) XM_004367 6q14.3
568 R95439 Prostaglandin F synthase [AKR 1C3] AB032154 10p15.1
136* R30667 Prostaglandin D2 synthase (21 kD, brain) XM_038059 9q34.3
184* R36792 Spermidine/spermine N1-acetyltransferase XM_041454 Xp22.11
474 R88367 Uridine-cytidine kinase NM_031432 9q34.2
138* - URF-1 (NADH dehydrogenase subunit) - -
246* - URF-2 (NADH dehydrogenase subunit) - -
3* - URF-4 (NADH dehydrogenase subunit) - -
290* - URF-5 (NADH dehydrogenase subunit) - -
41* - URF-A6L (ATPase 6) - -
55* - Cytochrome b - -
190* - Cytochrome C Oxidase I - -
206* - Cytochrome C Oxidase II - -
50* - Cytochrome C Oxidase III - -
Iron metabolism
646* R95476 Ferritin heavy polypetide 1 BC000857 11q13.1
358 R45918 Ferritin L-chain XM_050469 19q13.32
671* R95492 Transferrin receptor (p90, CD71) BC001188 3q29
Melanin synthesis
421* R47208 Tyrosinase related protein 1 X51420 9p23
353* R45915 Myosin VA (heavy polypeptide 12, myosin) U90942 15q21.2
516 R88387 Tyrosinase-related protein-2/DOPAchrome XM_036440 13q32.1
tautomerase
Antioxidant proteins
71* R30661 Selenoprotein P XM_011306 8q21.3,
5p12
566* R95438 Glutathione peroxidase 3 (plasma) XM_003684 5q33.1
416, R47205, 15 kD Selenoprotein XM_001568 1p22.3
432 R47214
Miscellaneous
211* R36800 Pigment epithelium-derived factor (PEDF) NM_002615 17p13.3
189 R36793 Meningioma expressed antigen 5 (hyaluronidase) XM_011925 10q24.32
247* R36816 snRNPE protein pseudogene E. B - -
388 R47194 PEG10 Paternally expressed 10 AB028974 7q21.2
285* R36832 Cysteine and glycine rich peptide U57646 12q21.1
220* R36839 Glucose transporter-like protein III AF274892 12p13.31
394* R47199 Wilm's tumor related protein (QM) XM_048417 -
426* R47211 Regulator of chromosome condensation D00591 -
609* R95458 Transposable element - -
460 R88357 Brain and reproductive organ-expressed protein NM_004899 2p23.2
628 R95466 Staufen (RNA binding-protein) XM_016758 20q13.13
481 R88402 Myxovirus (influenza) resistance 1, homolog of murine XM_009773 21q22.3
(interferon-inducible protein p78)
559* R95434 ATP-binding cassette, sub-family D (ALD), member 3 XM_040463 1p21.3
472 R88365 Similar to retinal degeneration B beta XM_038196 -
244* R36814 Tumor protein, translationally-controlled 1, TPT1 XM_038391 -
217* R36804 Basigin XM_055722 -
539 R88397 Down syndrome critical region gene 1-like 1 XM_004495 6p21.1
415 R47204 Meis1 (mouse) homolog XM_010880 2p13.3
212 R36801 Vitamin D3 up-regulated protein 1 AB051901 1q21.1
370* R45923 Cyclophilin A XM_057291 -
405* R47201 Laminin binding protein (nem11) NM_002295 -
643 R95475 Homo sapiens, Similar to Nuclear pore complex interacting BC008178 16p
protein
63 R30659 Homo sapiens similar to polycystic kidney disease1 U24497 -
177 R36787 Insulin induced gene 1 NM_005542 -
599 R95450 Proline arginine-rich end leucine-rich repeat protein U29089 1q32.1
357 R45917 Alpha-2 type IV collagen (COL4A2) XM_049907
391 R47197 FAM8A1 Family with sequence similarity 8, member A1 AL050128 6p22
158* R36786 Apolipoprotein D XM_003067 3q29
602 R95452 Homo sapiens progesterone receptor membrane component 1 XM_010363 Xq24
(PGRMC1)
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