Table 3 of
Mukhopadhyay, Mol Vis 2002;
8:271-279.Table 3 of
Mukhopadhyay, Mol Vis 2002;
8:271-279.
Table 3. Putative site for initiation of translation in myocilin mRNA
The known mammalian myocilin human and rat homologues contain more than one AUG in the 5'-region of the mRNA with a potential of being the site for initiation of translation. The putative start sites for both the human and rat myocilins were determined following Kozak's consensus sequence for initiation of translation for eukaryotic mRNA. The bases marked in red matches the Kozak consensus sequence [19].
Kozak consensus G Predicted
sequence G C C A C C AUG G protein
-------------------- - - - - - - --- - ---------
Human myocilin
Neighboring sequence
to first AUG U C U G C A AUG A 504 aa
Neighboring sequence
to second AUG C C U G A G AUG C 490 aa
Rat myocilin
Neighboring sequence
to first AUG A U A C C G AUG C 502 aa
Neighboring sequence
to second AUG C C C A A G AUG C 489 aa
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