Figure 1 of
Wistow, Mol Vis 2002;
8:205-220.
Figure 1. Gene structure and alternative splicing for oculoglycan/opticin (Optc)
The cDNA sequence of Optc is shown mapped onto the human gene sequence taken from from the public version of the human genome. Intron sequence and intron gap lengths are shown in red. cDNA/exon sequence is shown in black. Coding sequence is shown in upper case and noncoding is lower case. The sequence that is deleted by alternative splicing is also in green, with the embedded SLRP class III signature enclosed in brackets. Leucine rich repeats are shown in blue. 5' and 3' flanking DNA sequences, possibly including additional 5' UTR, are shown in purple.
actgtctaacccaagccccagttcagacagcctccaccagagtccccacctttctggaag Ex1 ctgcagggctctccatccaggatccagaagcattgaaggggtaaggctcaaggttgaggc Int1 ...(1756 bp)...gatcgctgcccttcctcgtgcccacttgccaggaccagccgctga Ex2 M R L L A F L S L L A 11 agggattctcagtcccatctgactccccATGAGGCTCCTGGCTTTCCTGAGTCTGCTGGC L V L Q E T G T A S L P R K E R K R R E 31 CTTGGTGCTGCAGGAGACAGGGACAGCTTCTCTCCCAAGGAAGGAGAGGAAGAGGAGAGA E Q M P R E G D S F E V L P L R N D V L 51 GGAGCAGATGCCCAGGGAAGGCGATTCCTTTGAAGTTCTGCCTCTGCGGAATGATGTCCT N P D N Y G E V I D L S N Y E E L T D Y 71 GAACCCAGACAACTATGGTGAAGTCATTGACCTGAGCAACTATGAGGAGCTCACAGATTA G D Q L P E 77 TGGGGACCAACTCCCCGAGgtgagggacacagcagaccaactacattccctgcatgacac Int2 V K V T S L A 84 ...(734 bp)...tgtgtactctgtgctacatctccagGTTAAGGTGACTAGCCTCGCT Ex3 P A T S I S P A K S T T A P G T P S S N 104 CCTGCAACCAGCATCAGTCCCGCCAAGAGCACTACGGCTCCAGGGACACCCTCGTCAAAC P T M T R P T T A G L L L S S Q P N H 123 CCCACGATGACCAGACCTACTACAGCAGGGCTGCTACTGAGTTCCCAGCCCAACCATGgt Int3 ...(1620 bp)... G L P T [C L V C V C L G S S V Y C] D D 142 cagGTCTGCCCACCTGCCTGGTCTGCGTGTGCCTCGGTTCCTCTGTGTATTGCGATGACA Ex4 I D L E D I P P L P R R T A Y L Y A R F 162 TTGACCTAGAGGACATTCCTCCTCTTCCTCGGAGGACTGCCTACCTGTATGCACGCTTCA N R I S R I R A E D F K G L 176 ACCGCATCAGCCGTATCAGGGCCGAAGACTTCAAAGGGCTGAgtat...(854 bp)... Int4 T K L K R I D L S N N L I S S I D 193 acctctctcagCAAAGTTGAAGAGGATTGACCTCTCCAACAACCTCATTTCCTCCATCGA Ex5 N D A F R L L H A L Q D L I L P E N Q L 213 TAATGATGCCTTCCGCCTGCTACATGCCCTCCAGGACCTCATCCTCCCAGAGAACCAGTT E A L P V L P S G I E F L D V R L N R L 233 GGAAGCTCTGCCCGTGCTGCCCAGTGGCATTGAGTTCCTGGATGTCCGCCTAAATCGGCT Q S S G I Q P A A F R 244 CCAGAGCTCGGGGATACAGCCTGCAGCCTTCAGGgtgagtcaag...(>2500 bp)... Int5 A M E K L Q F 251 ggacccaccagcctcctacactctttgctttctccacagGCAATGGAGAAGCTGCAGTTC Ex6 L Y L S D N L L D S I P G P L P L S L R 271 CTTTACCTGTCAGACAACCTGCTGGATTCTATCCCGGGGCCTTTGCCCCTGAGCCTGCGC S V H L Q 276 TCTGTACACCTGCAGgtaaggagcaccacccagagcaagggtgata...(554 bp)... Int6 N N L I E T M Q R D V F C D P 291 atgtgttcttcccagAATAACCTGATAGAGACCATGCAGAGAGACGTCTTCTGTGACCCC Ex7 E E H K H T R R Q L E D I R L D G N P I 311 GAGGAGCACAAACACACCCGCAGGCAGCTGGAAGACATCCGCCTGGATGGCAACCCCATC N L S L F P S A Y F C L P R L P I G R F 331 AACCTCAGCCTCTTCCCCAGCGCCTACTTCTGCCTGCCTCGGCTCCCCATCGGCCGCTTC T * 332 ACGtagctcggagcccttccactcctcccaggtaagaaccctcca...(4935 bp)... Int7 tctctctcaaggtcatctcttggaccagcgggcatcacattctccagcagccgccatctc Ex8 acacgcctccctcctgtggccgccggcagcatggacaaaggtctccatgcagggggagga ggcctgcttctttccccacagctctcacgtctcccttctccctgcgggtgacaaagaagc ccaaggaccacctccttcctgcctcattgtaataaaattccccacactgaggccttcttg tcttcaacctggcctgtccagcccttccagatatggccaaacccatggcctggatgggct |