Figure 5. Alternative splicing in exon 2 in the 5' UTR of human arrestin (S-antigen)

Spliced transcript (mRNA) sequence is shown in upper case. Black type shows sequence from exon 1 and the major splice form of exon 2, taken from hd/he ESTs. Red type shows the extension of exon 2 created by the alternative splicing. The intronic gt/ag dinucleotides of the alternative splice site are shown in lower case and in blue.

Exon 1
TGGATGCTGGGCATCCTCGCTAGATCCCCTACAAATTCCCCACATACGTAGGCCAGGAGCCT

CAGCGGTGCCCCTTCAGGCTCATCTGGCAAGACGGTACCAGCTTGCTCAGAACAGGGGCTGG

CTATTCATCATCTCAGAGCATAGAGACCCTCTCCTTGCCACCCGGCCCTTCCCACCTGGTTG

                 <-- 1067 bp -->  Alternative splice form
GTGACAAATCACAAGgt...         ...agGATTGTCTTACCTTTCTCCAACCCGACC

           Exon 2
AACACCCCAAGGTGGTAGAAGTTGCCA...