Figure 1 of
Ryan, Mol Vis 2001;
7:222-227.Figure 1 of
Ryan, Mol Vis 2001;
7:222-227.
Figure 1. Gb 1, 3, and 5 peptide sequence alignment
Multiple sequence alignment of amino acid sequences (GCG Pretty, used with a Blosum 62 scoring matrix) for Gb1 (A), Gb3 (B) and Gb5 (C) cloned from a salamander retina cDNA library. The conserved line of residues shows identity shared between all three subunits. Numbering is coordinated with the b1 and b3.
-50 0
Beta 1 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Beta 3 ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~ ~~~~~~~~~~
Beta 5 MCDQTFAAAV FGPCSKCGCE RPLRTIYKKS LPVTICSLCV ELMATEGLHE
1 50
Beta 1 MSELEQLRQE AEQLKNQIRD ARKVCADATL AQITANIDPV GRIQMRTRRT
Beta 3 MGGMEQLRQE AEQLKKQIAE ARKVCADTTL AQITAGMEVV GRIQMRTRRT
Beta 5 NETLTSLKNE ADSLKGKLEE ERAKLHDVEL HQVADRVESL GQFVMKTRRT
Conserved ------L--E A--LK----- -R----D--L -Q-------- G---M-TRRT
51 100
Beta 1 LRGHLAKIYA MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV
Beta 3 LRGHLAKIYA MHWSNDSRLL VSASQDGKLI VWDTYSTNKV HAIPLRSSWV
Beta 5 LKGHGNKVLC MDWCKDKRRI VSSSQDGKVI VWDAFTTNKE HAVTMPCTWV
Conserved L-GH--K--- M-W--D-R-- VS-SQDGK-I -WD---TNK- HA------WV
101 148
Beta 1 MTCAYAPSGN YVACGGLDNI CSIYNL..KT REGNVRVSRE LAGHTGYLSC
Beta 3 MTCSYAPSGN FVACGGLDNM CSIYNL..KT REGNVKVSRE LAAHTGYLSC
Beta 5 MACAYAPSGC AIACGGLDNK CSVYPLTFDK NENMASKKKS VAMHTNYLSA
Conserved M-C-YAPSG- --ACGGLDN- CS-Y-L---- -E-------- ---HT-YLS-
149 195
Beta 1 CRFID.DNQI ITSSGDTTCA LWDIETGQQT TTFAGHTGDV MSLSLAPD..
Beta 3 CRFLD.DNQI VTSSGDTTCA LWDIETGTQK TVFMGHTGDC MSLAVSPD..
Beta 5 CSFTNSDMQI LTASGDGTCA LWDVESGQLL QSFHGHGADV LCLDLAPSET
Conserved C-F---D-QI -T-SGD-TCA LWD-E-G--- --F-GH--D- --L---P---
196 245
Beta 1 SRCFVSGACD ASAKLWDVRE GMCRQTFTGH ESDINAICFF PNGNAFATGS
Beta 3 FRIFVSGACD ATAKLWDIRE GTCRQTFTGH ESDINAICFF PNGEAVCTGS
Beta 5 GNTFVSGGCD KKAMVWDMRS GQCIQSFETH ESDINSVRYY PSGDAFASGS
Conserved ---FVSG-CD --A--WD-R- G-C-Q-F--H ESDIN----- P-G-A---GS
246 295
Beta 1 DDATCRLFDL RADQELMVYS HDNIICGITS VAFSKSGRLL LAGYDDFNCN
Beta 3 DDATCRLFDL RADQELTVYS HESIICGITS VAFSRSGRLL LAGYDDFNCN
Beta 5 DDATCRLFDL RADREVAIYT KESIIFGASS VDFSLSGRLL FAGYNDYTIN
Conserved DDATCRLFDL RAD-E---Y- ---II----S V-FS-SGRLL -AGY-D---N
296 340
Beta 1 VWDTLKADRA GVLAGHDNRV SCLGVTDDGM AVATGSWDSF LKIWN*
Beta 3 MWDSMKGERV GVLSGHDNRV SCLGVTTDGM AAATGSWDSF LKIWN*
Beta 5 VWDVLKGTRV SILFGHENRV STLRVSPDGT AFCSGSWDHT LRIWA*
Conserved -WD--K--R- --L-GH-NRV S-L-V--DG- A---GSWD-- L-IW-
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