Figure 1 of
Lewis, Mol Vis 2001;
Figure 1. Molecular structures of aldose reductase inhibitors
Molecular structures of sorbinil, tolrestat, epalrestat, and six novel inhibitors (HAR-1 through HAR-6) are shown below. HAR-1 is 1H,7H-5a,6,8,9-tetrahydro-1-oxopyrano-[4,3-b]benzopyran-3-acetic acid, and is referred to as HAR-1 in the text. The synthesis of HAR-1 through HAR-6 is described in the text, under methods, and in .