Figure 3. Retinas are not protected from degeneration by mannose as evidenced by aberrant ultrastructure and immunolabeling patterns.

A. The morphology of the outer segment membranes is very similar to degenerating retinas with no sugar added. The ultrastructure indicates that membranous whorls lacking an orderly array are present. In addition, many inner segments are missing. B. The immunolabeling pattern of opsin reflects also the disorganization of the outer segments. C. Similarly, the rds/peripherin labeling pattern lacks the linear pattern noted in control retinas. Bar = 10 µm.