Figure 4. Families 4, 5, 6, and 7: Pedigrees and SSCP analyses of polymorphisms in exon 2 of the hLF gene used to investigate the relationship between the hLF genotype and FSCA in Families 2-11.

When consanguineous unions results in FSCA affected individuals, homogeneity would be expected in the allele of the gene causing FSCA. In families 4, 5, 6 and 7 (A, B, C, and D respectively), the affected individuals are heterozygous for hLF exon 2 SSCP banding polymorphisms.